| Size | Price | Stock | Qty |
|---|---|---|---|
| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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Cardamonin is a naturally occurring chalcone compound found in Alpinia katsumadai Hayata, acting as an aryl hydrocarbon receptor (AhR) activator and may be used for IBD/inflammatory bowel disease by inhibiting NLRP3 inflammasome activation via the AhR/Nrf2/NQO1 pathway.
| ln Vitro |
Treatment with cardamonin (5–40 μM) for 24 or 48 hours stops the proliferation of stomach cancer cells [3]. A treatment with cardamonin (10-30 μM) for 24 or 48 hours can control the expression of proteins linked to apoptosis [3]. Treatment with cardamonin (10-30 μM) for 24 or 48 hours can prevent STAT3 phosphorylation [3]. Treatment of HL-1 cells with cardaminin (0-100 μM) for 24 hours can increase their antioxidant capacity [4].
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|---|---|
| ln Vivo |
Oral administration of cardonin (20, 40, or 80 mg/kg; once) reduced the cardiotoxicity caused by doxorubicin and prevented mice challenged with doxorubicin from undergoing apoptosis [4].
|
| Cell Assay |
Cell Viability Assay[3]
Cell Types: AGS, MGC-803, BGC-823 Cell Tested Concentrations: 5, 10, 20, 30, 40 μM Incubation Duration: 24 or 48 hrs (hours) Experimental Results: Inhibition of cell growth in a concentration-dependent manner. Western Blot Analysis[3] Cell Types: AGS, MGC-803, BGC-823 Cell Tested Concentrations: 10, 20, 30 μM Incubation Duration: 24 or 48 hrs (hours) Experimental Results: Bcl-2 downregulation, Bax protein expression increased, Bax protein expression increased Caspase-3 protein expression levels. Western Blot Analysis[3] Cell Types: AGS Cell Tested Concentrations: 10, 20, 30 μM Incubation Duration: 24 or 48 hrs (hours) Experimental Results: Inhibition of STAT3 phosphorylation levels. Western Blot Analysis[4] Cell Types: HL-1 Cell Tested Concentrations: 0, 25, 50, 100 μM Incubation Duration: 24 hrs (hours) Experimental Results: Demonstrated antioxidant effects in doxorubicin-stimulated cardiomyocytes. |
| Animal Protocol |
Animal/Disease Models: Male C57BL/6 J mice (8 weeks old, 20-22 g) [4]
Doses: 20, 40 or 80 mg/kg Route of Administration: po (oral gavage); 20, 40 or 80 mg/kg; Experimental Results: It rescued the decrease in LVEF% and LVFS% caused by doxorubicin, diminished the increase in serum LDH, CK-MB and Tn-T levels caused by doxorubicin in a dose-dependent manner, and improved the histological changes caused by doxorubicin. and attenuated collagen accumulation in cardiac slices by doxorubicin in a dose-dependent manner. Animal/Disease Models: Male C57BL/6 J mice (8 weeks old, 20-22 g) [4] Doses: 20, 40 or 80 mg/kg Route of Administration: po (oral gavage); 20, 40 or 80 mg/kg; Experimental Results: Bcl-2 was rescued in the heart tissue of mice challenged with doxorubicin, and the cleavage of Bax and Caspase-3 was inhibited. |
| References |
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| Additional Infomation |
Cardamonin is a member of chalcones.
Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human health. Cardamonin's name comes from the fact that it can be found in cardamom spice. Cardamonin has been reported in Cedrelopsis grevei, Boesenbergia rotunda, and other organisms with data available. |
| Molecular Formula |
C16H14O4
|
|---|---|
| Molecular Weight |
270.2800
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| Exact Mass |
270.089
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| CAS # |
18956-16-6
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| PubChem CID |
641785
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.282g/cm3
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| Boiling Point |
484.5ºC at 760 mmHg
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| Flash Point |
182.7ºC
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| Vapour Pressure |
5.2E-10mmHg at 25°C
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| Index of Refraction |
1.657
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| LogP |
3.002
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
20
|
| Complexity |
346
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
COC1=CC(=CC(=C1C(=O)/C=C/C2=CC=CC=C2)O)O
|
| InChi Key |
NYSZJNUIVUBQMM-BQYQJAHWSA-N
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| InChi Code |
InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
|
| Chemical Name |
(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~462.48 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.17 mg/mL (8.03 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6999 mL | 18.4993 mL | 36.9987 mL | |
| 5 mM | 0.7400 mL | 3.6999 mL | 7.3997 mL | |
| 10 mM | 0.3700 mL | 1.8499 mL | 3.6999 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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