FAK

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

+MORE

FAK

FAK (Focal Adhesion Kinase, or PTK2) is a protein tyrosine kinase that is not associated with receptors and is not located on membranes. It is activated at the sites of integrin clustering and cell-matrix adhesions by autophosphorylation (at Tyr397), Src, and other tyrosine kinases. By transferring signals governing cell migration, adhesion, and survival from the extracellular matrix to the cytoplasm, FAK mediates integrin-based cell signaling.

Many tumors, including those from the head and neck, colon, breast, prostate, liver, and thyroid, overexpress FAK. Additionally, in these tumors, FAK overexpression is strongly associated with an invasive phenotype. Glioblastomas and ovarian cancer cells are less likely to invade when dominant-negative FAK fragments are overexpressed and FAK signaling is inhibited. FAK is a crucial target for the creation of anti-metastatic and anti-neoplastic medications.

FAK related products

Cat No.	Product Name	CAS No.	Product Description
V69723	Adhesamine	462605-73-8	Adhesamine is a dumbbell-shaped molecule that activates the MAPK/FAK pathway.
V69722	Batatasin III	56684-87-8	Batatasin III is a stilbene compound that can inhibit cancer migration and invasion by inhibiting epithelial-mesenchymal transition (EMT) and FAK-AKT signaling.
V4437	BI-4464	1227948-02-8	BI-4464 is a novel, potent and highly selective ATP competitive inhibitor ofPTK2/FAKwith anIC50of 17 nM.
V3209	Defactinib HCl	1073160-26-5	Defactinib HCl (formerly known as VS-6063 HCl, PF-04554878 HCl) is a novel, potent, selective, and orally bioactive small molecule inhibitor of the FAK (focal adhesion kinase), it inhibits thephosphorylation of FAK at the Tyr397 site in a time- and dose-dependent manner.
V69726	FAK inhibitor 2	2354405-14-2	FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor (antagonist) with IC50 of 0.07 nM and has anti-tumor and anti-angiogenic activities.
V69728	FAK inhibitor 6	2410056-27-6	Compound 26f not only optimized to effectively inhibit the enzyme (IC50= 28.2 nM), but also showed relatively little cytotoxic effect (IC50= 3.32 μM), and induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in G0/G1 phase.
V69731	FAK-IN-1	2553215-22-6	FAK-IN-1 is a FAK inhibitor (antagonist) with anti-cancer activity (WO2020231726 (Example 27)).
V69730	FAK-IN-10	491839-65-7	FAK-IN-10 is an inhibitor (blocker/antagonist) of FAK with IC50 of 76.3 μM.
V79377	FAK-IN-11		FAK-IN-11 (Compound 4l) is a FAK inhibitor.
V79378	FAK-IN-12		FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC50 = 47 nM).
V69721	FAK-IN-14	2766666-22-0	FAK-IN-14 (compound 8d) is a focal adhesion kinase (FAK) inhibitor (antagonist) with IC50 of 0.2438 nM.
V79379	FAK-IN-15		FAK-IN-15 (Compound 9b) is a focal adhesion kinase (FAK) inhibitor (antagonist) with IC50 of 0.2691 nM.
V69724	FAK-IN-2	2872588-02-6	FAK-IN-2 is a potent and orally bioactive focal adhesion kinase (FAK) inhibitor (antagonist) with anti-tumor activity (FAK IC50= 35 nM).
V69729	FAK-IN-3	2882094-29-1	FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK).
V69727	FAK-IN-9	2911655-93-9	FAK-IN-9 (Compound 8f) is a potent and orally bioactive FAK inhibitor (antagonist) with IC50 of 27.44 nM.
V69720	FC-11	2271035-37-9	FC-11 is a PROTAC FAK degrader (DC90: 1 nM).
V2836	GSK2256098	1224887-10-8	GSK2256098 is a small molecule developed by GlaxoSmithKline) as a selective FAK (Focal Adhesion Kinase) kinase inhibitor to inhibit FAK activity through targeting the phosphorylation site of FAK, tyrosine (Y) 397.
V69725	Petunidin chloride	1429-30-7	Petunidin chloride is an O-methylated anthocyanin derived from silymarin.
V28341	Y11	1086639-59-9	Y11 (Y-11) is a novel and potent small molecule inhibitor of FAK (focal adhesion kinase) with potential anticancer activity.
V3389	Y15	4506-66-5	Y15 (also known as FAK inhibitor Y15 and FAK Inhibitor 14) is a novel, potent, specific and direct inhibitor of focal adhesion kinase (FAK) which blocks phosphorylation of Y397 with an IC50 value of about 1 μM.