HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3772 | ACY-775 | 1375466-18-4 | ACY-775, anovel pyrimidine hydroxyl amide small molecule, is a brain bioavailable, highly potent and isoform-selective inhibitor of HDAC6 with IC50of 7.5 nM. |
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V2346 | AES-350 | 847249-57-4 | AES-350 is a potent orally bioactive HDAC6 inhibitor (antagonist) with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. |
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V11458 | Apicidin | 183506-66-3 | Apicidin (OSI-2040; OSI2040) is a novel and potent histone deacetylases (HDAC) inhibitor and apoptosis inducer with potential anticancer activity. |
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V9315 | BRD6688 | 1404562-17-9 | BRD6688 (BRD-6688; BRD 6688) is a novel and potent HDAC1/2/3 inhibitor with IC50s of 21 nM, 100 nM, and 11.48 μM, respectively. |
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V3843 | Chidamide (Tucidinostat, HBI8000, CS 055) | 1616493-44-7 | Chidamide (CS-055, Tucidinostat, HBI-8000; trade name: Epidaza), is a potent and orally bioavailable benzamide-type histone deacetylase (HDAC) inhibitor with IC50s of 95, 160, 67 and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10, respectively. |
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V3681 | Citarinostat (ACY241) | 1316215-12-9 | Citarinostat (ACY-241; ACY241;HDAC-IN-2) is a novel, potent, orally bioavailable and selective inhibitor of HDAC6 (histone deacetylase) with anticancer activity. |
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V18790 | Crebinostat | 1092061-61-4 | Crebinostat is a novel and potent HDAC (histone deacetylase) inhibitor with anticancer and neuroprotective effects. |
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V31524 | FT895 | 2225728-57-2 | FT895 is a potent and specific HDAC11 inhibitor (antagonist) with IC50 of 3 nM. |
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V3845 | Givinostat | 497833-27-9 | Givinostat (formerlyknown asITF-2357; Gavinostat)is a potent and orally bioactive inhibitor of both class I and class II histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and anticancer activities. |
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V3844 | Givinostat HCl | 199657-29-9 | Givinostat (ITF-2357 hydrochloride)is a potent andorally bioactive HDAC inhibitor with potential anti-inflammatory, anti-angiogenic, and anticancer activities. |
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V51325 | HDAC-IN-53 | 2921948-27-6 | HDAC-IN-53 is a novel HDAC1-3 inhibitor that has IC50 values of 47 nM, 125 nM, and 450 nM, in that order. |
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V50906 | HDAC8 PROTAC degrader 1 | HDAC8 PROTAC degrader 1 is a HDAC8 PROTAC degrader. | |
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V25196 | HDAC8-IN-1 | 1417997-93-3 | HDAC8-IN-1 is a novel and potent HDAC8 inhibitor with an IC50 of 27.2 nM. |
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V51712 | IDO1 and HDAC1 Inhibitor | 2227044-16-6 | IDO1 and HDAC1 Inhibitor is a novel dual inhibitor of HDAC1 and IDO1, with IC50 values of 66.5 nM and 69.0 nM, respectively. |
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V50953 | ITF-3985 | ITF-3985 HDAC6 is a novel HDAC6 inhibitor. | |
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V27646 | Pivanex | 122110-53-6 | Pivanex (AN-9; AN 9; AN9; pivaloyloxymethyl butyrate; Titan) is a novel and potent histone deacetylase/HDAC inhibitor with anticancer and antiangiogenic properties. |
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V3761 | Remetinostat | 946150-57-8 | Remetinostat (formerly known as SHP-141) is an inhibitor of histone deacetylase (HDAC) developed by Medivir as a topical application for use in early stage CTCL (Cutaneous T-cell lymphoma). |
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V3846 | Resminostat HCl | 1187075-34-8 | Resminostat HCl (formerly known as RAS-2410; RAS2410 and 4SC-201), the hydrochloride salt of Resminostat, is a potent inhibitor of HDAC (histone deacetylase) classes I and II (including HDAC1/3/6) with anticancer activity. |
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V4636 | SW-100 | 2126744-35-0 | SW-100 (SW100),a tetrahydroquinoline-based compound, is a novel, potent, brain penetrant and selectivehistone deacetylase 6 (HDAC6)inhibitor (IC50 = 2.3 nM) with neuroprotective effects. |
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V4083 | TH34 | 2196203-96-8 | TH34 is a novel, potent and selective HDAC6/8/10 (histone deacetylase) inhibitor for neuroblastoma therapy. |
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