Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. Ras is the representative member of the Ras superfamily, a group of proteins that all share a common 3D structure and control a variety of cell behaviors. Incoming signals that activate Ras then activate other proteins, which in turn activate genes necessary for cell growth, differentiation, and survival. Ras proteins that are permanently activated can therefore be produced as a result of ras gene mutations.Even in the absence of incoming signals, this may result in unintended and excessive signaling within the cell. Overactive Ras signaling can ultimately result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the 3 Ras genes (HRAS, KRAS, and NRAS), and Ras inhibitors are being researched as a potential treatment for cancer and other conditions characterized by Ras overexpression.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51415 | (S)-JDQ-443 ((S)-NVP-JDQ443) | 2653994-10-4 | (S)-JDQ-443 is an isomer of JDQ-443 . |
|
V11400 | Antineoplaston A 10 | 91531-30-5 | Antineoplaston A10 exists naturally in the human body and is an inhibitor (blocker/antagonist) of Ras. |
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V51547 | Antitumor compound 5a | 2907704-65-6 | Antitumor compound 5a, has an IC50 value of 2.62 µM, meaning that it inhibits MCF-7 breast cancer cells. |
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V51473 | ARS-1323-alkyne | 2436544-27-1 | ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, a conformationally specific chemical reporter of the KRASG12C nucleotide state in living cells, is a switch-II pocket (S-IIP) inhibitor. |
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V51452 | ARS-2102 | 2098509-21-6 | ARS-2102 is a potent covalent KRAS G12C inhibitor for cancer research. |
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V51458 | ASP-2453 | 2241719-73-1 | ASP2453 is a novel and covalent inhibitor of KRAS G12C. |
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V51469 | Atrovastatin-PEG3-FITC | 1440755-31-6 | Atorvastatin-PEG3-FITC (compound S31) is a KRAS-PDEδ interaction inhibitor. |
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V77220 | AZD4747 | AZD4747 is a selective, BBB (blood-brain barrier) permeable/penetrable inhibitor of the mutant GTPase KRASG12C. | |
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V51467 | BI-0474 | 2750570-55-7 | BI-0474 is a strong inhibitor of KRASG12C, with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. |
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V51450 | BI-2865 | 2937327-93-8 | BI-2865 is a novel inhibitor of KRAS G12C. |
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V51195 | BI-2865 | 2937327-93-8 | BI-2865 is a novel inhibitor of KRAS G12C. |
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V1902 | BQU57 | 1637739-82-2 | BQU57, a derivative of RBC8, is a novel and selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. |
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V67543 | CCG-232964 | 2349373-70-0 | CCG-232964 is an orally bioactive Rho/MRTF/SRF inhibitor. |
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V51475 | CFL-120 | 18711-15-4 | CFL-120 is a selective KRasG12C inhibitor. |
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V51476 | CFL-137 | 708-06-5 | CFL-137 is a selective KRasG12C inhibitor. |
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V51643 | CMC2.24 (TRB-N0224) | 1255639-43-0 | CMC2.24 (TRB-N0224), an oral active tricarbonylmethane agent that inhibits Ras activation and the downstream effector pathway ERK1/2 to effectively treat pancreatic tumors in mice. |
|
V69786 | CX-5011 | 1333382-30-1 | CX-5011 is a CK2 inhibitor. |
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V74143 | Cyclorasin 9A5 | 1782098-79-6 | Cyclorasin 9A5 is an 11-residue cell-penetrable cyclic peptide that can inhibit the Ras-Raf protein interaction with IC50 of 120 nM. |
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V4001 | Exo1 | 75541-83-2 | Exo-1 (Exo1)is a novel, potent and reversible inhibitor of exocytosis which is used as a chemical inhibitor of theexocytic pathway. |
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V51462 | Fulzerasib | 2641747-54-6 | Fulzerasib is a potent KRAS inhibitor. |
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