The G protein-coupled receptor family, which includes the glucagon receptor (GCGR), is crucial for regulating blood sugar levels. The class B G-protein coupled family of receptors includes the glucagon receptor, a 62 kDa protein that is activated by glucagon and coupled to G alpha i, Gs, and to a lesser extent G alpha q. Adenylate cyclase is activated and intracellular cAMP levels are raised when the receptor is stimulated. The GCGR gene in humans is responsible for encoding the glucagon receptor. The liver and kidneys are the primary sites of glucagon receptor expression, with smaller amounts of these receptors also present in the heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74594 | [Des-His1,Glu9] Glucagon | 110121-11-4 | [Des-His1,Glu9] Glucagon is a potent peptide antagonist of the glucagon receptor system. |
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V77345 | [Des-His1,Glu9]-Glucagon amide TFA | [Des-His1,Glu9]-Glucagon amide TFA is a potent peptide antagonist of the glucagon receptor with a pA2 value of 7.2. | |
|
V74593 | A8SGLP-1 | 753024-08-7 | A8SGLP-1 is an orally bioactive GLP-1 analog in which alanine at position 8 is replaced by serine. |
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V77707 | A8SGLP-1 TFA | A8SGLP-1 TFA is an orally bioactive GLP-1 analog in which alanine at position 8 is replaced by serine. | |
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V4891 | Adomeglivant (LY2409021) | 1488363-78-5 | Adomeglivant (formerly known as LY-2409021) is a novel, potent and selective glucagon receptor antagonist that is being investigated in clinical trial for type 2 diabetes mellitus. |
|
V33194 | Avexitide | 133514-43-9 | Avexitide [Exendin-3 (9-39)] is a novel, competitive and peptidic antagonist of glucagon-like peptide-1 (GLP-1) receptor with a Kd of 1.7 nM at cloned human GLP-1 receptors. |
|
V51719 | Bay 55-9837 | 463930-25-8 | VPAC2 agonist |
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V78347 | Bay 55-9837 TFA | Bay 55-9837 TFA is a potent and selective VPAC2 agonist/activator with a Kd of 0.65 nM. | |
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V33070 | BETP | 1371569-69-5 | BETP is a novel and potent PAM (positive allosteric modulator) and partial agonist of glucagon-like peptide-1 (GLP-1) receptor (EC50= 0.66 μM) with antidiabetic effects. |
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V78466 | Biotinyl-Glucagon (1-29), human, bovine, porcine | Biotinyl-Glucagon (1-29), human, bovine, porcine is a biomarker of Glucagon, a peptide hormone produced by pancreatic alpha cells that increases the concentration of glucose and fatty acids in the blood. | |
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V74587 | Cotadutide (MEDI0382) | 1686108-82-6 | Cotadutide (MEDI0382) is a potent dual glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR) agonist/activator with EC50s of 6.9 pM and 10.2 pM, respectively. |
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V74573 | Crotedumab (REGN1193; Anti-GCGR Reference Antibody (crotedumab)) | 1452387-69-7 | Crotedumab (REGN1193) is a humanized IgG4 monoclonal antibody (mAb) that binds and inhibits the glucagon receptor (GCGR) with a KD of 0.1 nM. |
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V74568 | Dapiglutide (ZP7570) | 2296814-85-0 | Dapiglutide (ZP7570) is a long-acting glucagon-like peptide 1 receptor (GLP-1R)/glucagon-like peptide 2 receptor (GLP-2R) dual agonist. |
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V79079 | Des His1, Glu8 Exendin-4 | Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. | |
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V41550 | Dulaglutide (Trulicity; LY2189265) | 923950-08-7 | Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist (activator). |
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V51122 | Ecnoglutide | 2459531-73-6 | Ecnoglutide (XW003) is a glucagon-like peptide 1 (GLP-1) receptor agonist (activator). |
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V74581 | Elsiglutide (ZP1846) | 914009-84-0 | Elsiglutide (ZP1846) is a GLP-2 analog and an orally bioactive and selective GLP-2 receptor agonist that increases cell proliferation/growth and reduces intestinal cell apoptosis (apoptosis). |
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V32928 | Exenatide (Exendin-4) | 141758-74-9 | Exenatide (Exendin-4), a bioactive peptide composed of 39 amino acids, is antidiabetic medication acting as a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. |
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V74595 | Exendin (5-39) | 196109-27-0 | Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1 receptor) receptor antagonist. |
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V74580 | Exendin-3/4 (59-86) | 1263874-37-8 | Exendin-3/4 (59-86) is an Exendin-4 peptide analogue. |
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