CaMK

CaMK

It has been established that the Ca2+/calmodulin-dependent kinase (CaMK) family is an important mediator in living things and numerous biological processes.

CaMK II is a multifunctional protein kinase that phosphorylates and modifies the function of a wide range of substrates in the cytoplasm in response to calcium and calmodulin. It has been discovered that the cAMP-response element binding protein (CREB) pathway controls the RANKL-induced osteoclast formation through the CaMK II pathway.
Intracellular calciumol/L has been repeatedly shown to be crucial among the many signaling pathways of proliferation. Calciumol/L activates the CaMKs, a family of structurally related serine/threonine protein kinases, including CaMKI-IV, in the cytoplasm by binding to calmodulin. Cell cycle, apoptosis, gene expression, and neurotransmission are just a few of the physiological processes that CaMKII, a multifunctional protein kinase, is constantly involved in.

CaMK related products

Structure Cat No. Product Name CAS No. Product Description
V32904 A-484954 142557-61-7 A-484954 (A484954; A 484954) is a highly selective,cell-permeable andATP-competitive eukaryotic elongation factor-2 (eEF2) inhibitor with potential antitumor activity.
V77730 AC3-I, myristoylated (Autocamtide-3 Derived Inhibitory Peptide) AC3-I, myristoylated is a biologically active peptide.
V71550 Autocamtide-3 142828-10-2 Autocamtide-3 is a 13 amino acid (AA) peptide containing Thr287 and is a selective CaMKII (Ca2+/calmodulin-dependent kinase II) (CaMK) substrate.
V77224 Autocamtide-3 acetate Autocamtide-3 acetate is a 13 amino acid (AA) peptide containing Thr287 and is a selective CaMKII (Ca2+/calmodulin-dependent kinase II) (CaMK) substrate.
V52993 Cabamiquine succinate (DDD107498 succinate; DDD-498 succinate; M5717 succinate) 2444781-71-7 Cabamiquine (DDD107498) succinate is a potent, orally bioavailable antimalarial agent that can inhibit multiple stages of the parasite life cycle, with EC50 of 1 nM against P. falciparum 3D7.
V71545 Calmodulin Dependent Protein Kinase Substrate 82801-68-1 Calmodulin Dependent Protein Kinase Substrate is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide.
V71549 Calmodulin Dependent Protein Kinase Substrate Analog 123067-01-6 Calmodulin Dependent Protein Kinase Substrate Analog is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide.
V78611 Calmodulin Kinase IINtide, Myristoylated (Myr-CaMKIINtide) Calmodulin Kinase IINtide, Myristoylated (Myr-CaMKIINtide) is a selective and noncompetitive CaMKII inhibitor.
V71547 CaMKII inhibitory peptide KIIN (Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ) 508181-45-1 CaMKII inhibitory peptide KIIN is a potent inhibitor of CaMKII.
V3429 CaMKII-IN-1 1208123-85-6 CaMKII-IN-1, a5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine analog, is a novel, potent and highly selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) inhibitor with IC50 of 63 nM.
V71544 CS587 2388506-69-0 CS587 is a specific inhibitor of CaMK1D and is neurotoxic at 10 μM.
V1298 KN-62 127191-97-3 KN-62 (KN62; KN 62) is a potent, selective, cell-permeable and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with potential anticancer activity.
V2578 KN-92 176708-42-2 KN-92 is an inactive derivative of KN-93.
V2803 KN-92 Hydrochloride 1431698-47-3 KN-92 Hydrochloride, the hydrochloride salt of KN-92, is an inactive derivative of KN-93.
V2802 KN-92 Phosphate 1135280-28-2 KN-92 Phosphate, the phosphate salt of KN-92, is an inactive derivative of KN-93.
V2580 KN-93 139298-40-1 KN-93 is a potent,cell-permeable, reversible and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, and withno remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
V2579 KN-93 HCl 1956426-56-4 KN-93 HClis a potent,cell-permeable, reversible and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, and withno remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
V1299 KN-93 Phosphate 1188890-41-6 KN-93 Phosphate (KN 93; KN93), the phosphate salt of KN-93, is a potent, cell-permeable and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with potential anti-Parkinsons disease and anticancer activity.
V13777 Lavendustin C 125697-93-0 Lavendustin C, formerly known as HDBA and NSC 666251, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 of 0.012 µM.
V1297 NH125 278603-08-0 NH125 (NH-125; NH 125) is a potent and selective eEF-2 (eukaryotic elongation factor 2) kinase inhibitor with antibacterial activity against various Gram-positive and -negative bacteria.
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