The epidermal growth factor receptor (EGFR; ErbB1) is a member of the epidermal growth factor RTK (receptor tyrosine kinases) family, along with HER2/neu (ErbB2), ErbB3 (HER3), and ErbB4 (HER4). The extracellular ligand-binding ectodomain, the single chain transmembrane domain, and the intracellular tyrosine kinase domain make up the EGFR, which is located at the cell surface. Epidermal growth factor (EGF), transforming growth factor (TGF-α), amphiregulin, heparin-binding EGF, and betacellulin are just a few of the ligands that bind to and activate the EGFR.
The tyrosine kinase domain is activated by the receptors' formation of homo- or heterodimeric complexes after ligand binding. The Ras-Raf-MAP kinase, PI-3K/Akt, PKC, and Stat/Jak signaling pathways are all activated as a result of the dimerization and autophosphorylation of EGFR. The EGFR is activated to control cellular survival, differentiation, and proliferation. The EGFR has been derided as a proto-oncogene primarily because of its function in encouraging cell proliferation and preventing apoptosis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51518 | (E/Z)-AG490 | 134036-52-5 | (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is the racemate of (E)-AG490 and (Z)-AG490. |
|
V51446 | EGFR-IN-76 | 2607829-38-7 | EGFR-IN-76 (compound 37A) is a potent reagent for EGFR. |
|
V83212 | JBJ-03-142-02 | 2068806-31-3 | JBJ-03-142-02 is an inhibitor of EGFR-HER2 Ex20Ins. |
|
V29472 | Lidocaine hydrochloride | 73-78-9 | Lidocaine hydrochloride monohydrate (also known as Alphacaine; Lignocaine) is a potent and selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
|
V50946 | Limertinib (ASK-120067) | 1934259-00-3 | Limertinib (ASK120067) is a potent epidermally active EGFRT790M (IC50= 0.3 nM) and selective for EGFRWT (IC50= 6.0 nM). |
|
V51017 | LS-106 | EGFR C797S inhibitor | |
|
V51197 | Mefatinib | 1417695-74-9 | pan- EGFR inhibitor |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
