Arenavirus

Arenavirus

Only four viral proteins—the envelope glycoprotein precursor, nucleocapsid protein, matrix zinc-binding (Z) protein, and large (L) RNA-dependent RNA polymerase (RdRp)—are encoded by the arenavirus genome's two ambisense RNA segments. The multi-domain L protein has both transcriptional and replicational functions. The replication of the arenavirus genome is de novo initiated and involves a complementary RNA (cRNA) intermediate, similar to other segmented negative-sense RNA viruses (sNSVs), whereas the transcription process likely requires a host mRNA-derived primer captured by the viral polymerase through cap snatching.

Lassa mammarenavirus, Machupo mammarenavirus, and lymphocytic choriomeningitis virus are three examples of arenaviruses that can cause severe haemorrhagic fever and neurological disorders in humans and other animals, posing serious risks to public health. The large multi-domain RNA-dependent RNA polymerase that these viruses encode is necessary for the transcription and replication of the viral genome. One of the main therapeutic targets for antiviral drugs is viral polymerases.

Arenavirus related products

Structure Cat No. Product Name CAS No. Product Description
V77384 (E)-LHF-535 (E)-LHF-535 is an isomer of LHF-535.
V52047 GP(33-41) 161928-86-5 GP(33-41) is a polypeptide consisting of 9 amino acid (AA) residues.
V51880 LASV inhibitor 3.3 554438-52-7 LASV inhibitor 3.3 is an inhibitor (blocker/antagonist) of Lassa fever virus (LASV).
V54157 LCMV GP (61-80) 232598-19-5 LCMV GP (61-80) is a polypeptide fragment derived from the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), corresponding to the amino acid (AA) sequence 61-80.
V76831 LCMV gp33-41 TFA LCMV gp33-41 (TFA), a carboxyl-extended 11-aa-long peptide, lymphocytic choriomeningitis virus sequence restricted to the MHC class I H-2Db molecule, is presented to cytotoxic T lymphocytes.
V32815 LHF-535 1450929-77-7 LHF-535 (LHF535) is a novel and potent antiviral agentwith EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
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