c-Myc

c-Myc

Transcriptional regulator The basic helix-loop-helix leucinezipper (bHLHZipper) protein family includes c-Myc. The c-MYC protein's target genes are involved in a variety of cellular processes, including the cell cycle, survival, protein synthesis, cell adhesion, and the expression of microRNAs. In addition, c-Myc, one of the four factors required for the induction of pluripotent stem (iPS) cells from somatic cells, is thought to contribute to the maintenance of cancer stem-like cells (CSCs). The majority of c-Myc'sbiologicalactivities necessitate heterodimerization with its activation partner Max.

Additionally, c-Myc is a component of a dynamic network, which interacts selectively with different transcriptional coregulators, histone-modifying enzymes, and members of the network. Tumorigenesis is linked to c-MYC expression that is dysregulated as a result of gene amplification, retroviral insertion, or chromosomal translocation. One extremely promising target for cancer treatment is c-Myc.

c-Myc related products

Structure Cat No. Product Name CAS No. Product Description
V79917 c-Myc inhibitor 11 c-Myc inhibitor 11 (Compound 67e) is a c-MYC inhibitor (pEC50= 6.4).
V79485 c-Myc inhibitor 12 c-Myc inhibitor 12 (compound 67h) is a c-Myc inhibitor (antagonist) with pEC50 of 6.4.
V2312 EN4 1197824-15-9 EN4 is a covalent ligand for cysteine 171 (C171) of MYC.
V77917 MDEG-541 MDEG-541 is an effective MYC-MAX degrader.
V76736 MYC-RIBOTAC MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) that targets the MYC internal ribosome entry site (IRES).
V4825 VPC-70063 13571-44-3 VPC-70063 is a potent Myc-Max inhibitor (antagonist) with IC50 of 8.9 μM for inhibiting Myc-Max transcriptional activity.
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