Caspase

Caspase

An important part of apoptosis (programmed cell death), necrosis, and inflammation is played by the cysteine protease family known as caspase. Apoptotic caspases come in two varieties: effector (executioner) caspases and initiator (apical) caspases. Effector caspases are activated when initiator caspases, such as CASP2, CASP8, CASP9, and CASP10, cleave their inactive pro-forms. In order to start the apoptotic process, effector caspases (such as CASP3, CASP6, and CASP7) cleave other protein substrates inside the cell. Caspase inhibitors control how this cascade reaction gets started. Because they are inflammatory enzymes that cooperate with CASP1 to play a role in T-cell maturation, CASP4 and CASP5, which are overexpressed in some cases of vitiligo and related autoimmune diseases brought on by NALP1 variants, are not currently classified as initiators or effectors in MeSH.

Caspase related products

Structure Cat No. Product Name CAS No. Product Description
V33252 2-HBA 131359-24-5 2-HBA, ananalog of curcumin,is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
V2376 20-Hydroxyecdysone (Crustecdysone) 5289-74-7 20-Hydroxyecdysone (also known as B-ecdysone, Crustecdysone, Commisterone Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.
V76052 Ac-AAVALLPAVLLALLAP-LEVD-CHO 886462-82-4 Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-penetrating/penetrable caspase-4 inhibitor (antagonist) with anti-tumor activity.
V76050 Ac-AAVALLPAVLLALLAP-YVAD-CHO 201608-12-0 Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-penetrating/penetrable caspase-1 inhibitor (antagonist) with anti-tumor activity.
V2777 Ac-DEVD-CHO 169332-60-9 Ac-DEVD-CHO is a potent and specific aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively.
V77300 Ac-DEVD-CMK TFA (Caspase-3 Inhibitor III TFA) Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor.
V75995 Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) 775289-20-8 Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50= 9.89, 245 nM, respectively; Kiapp: 0.68, 55.7 nM, respectively).
V75996 Ac-VAD-pNA 154564-07-5 Ac-VAD-pNA is a caspase-1 substrate.
V75998 Ac-VDVAD-pNA 189684-53-5 Ac-VDVAD-pNA is a caspase-2 substrate.
V75997 Ac-VETD-AMC 1135686-24-6 Ac-VETD-AMC is a synthetic peptide substrate for caspase 8.
V77291 Ac-WEHD-AFC TFA Ac-WEHD-AFC TFA is a fluorescent caspase-1 substrate.
V69263 ALK-IN-26 2447607-85-2 ALK-IN-26 (compound 4a) is an ALK inhibitor (antagonist) with IC50 of 7.0 μM for ALK tyrosine kinase.
V80024 Antiproliferative agent-42 antiproliferation agent-42 (compound 7m) is a dihydrodipyrrole compound.
V0026 Apoptosis Activator 2 79183-19-0 Apoptosis Activator 2 is a novel and potent small molecule apoptosis activator with IC50 value of about 4μM.
V33182 Aristolactam I 13395-02-3 Aristolactam I(AL-I) is a major metabolite of aristolochic acid I (AA-I), and is able toform DNA adducts, thus causingrenal damage.
V0024 Belnacasan (VX765) 273404-37-8 Belnacasan (also known as VX-765) is a novel, potent, selective and orally bioactive prodrug of VRT-043198 which is a potent and selective inhibitor of caspase-1 withKi values of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively.
V29824 BOC-D-FMK 634911-80-1 Boc-D-FMK is a cell-permeable, irreversible (covalent) and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
V78588 C105SR C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl prolyl trans-isomerase (PPIase).
V79078 Caspase-3 activator 2 Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that causes apoptosis and may be utilized in cancer research.
V79147 Caspase-3 activator 3 Caspase-3 activator 3 (compound 2h) can cause apoptosis in HL-60 and K562 cells by activating caspase 3.
Contact Us