RIP kinase

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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RIP kinase

Receptor-interacting protein (RIP) kinases are a class of threonine/serine protein kinases with distinct non-kinase regions and a comparatively conserved kinase domain. The RIPK family consists of seven members, RIPK1 to RIPK7, some of which have become important effectors of immunity against infection with a variety of bacterial, viral, and protozoal pathogens.

Both communicable and non-communicable disease processes depend on the cellular signaling molecules known as RIP kinases for homeostatic signaling. The early control of a wide range of pathogenic organisms requires the action of RIPK1, RIPK2, RIPK3, and RIPK7, which have emerged as important mediators of intracellular signal transduction including inflammation, autophagy, and programmed cell death.

RIP kinase related products

Cat No.	Product Name	CAS No.	Product Description
V77366	(Rac)-GSK547		(Rac)-GSK547 is the racemate of GSK547.
V51418	Desmethyl-WEHI-345 analog	1354825-03-8	protein kinase inhibitor
V2773	GSK' 872 (GSK2399872A)	1346546-69-7	GSK872 (also known asGSK2399872A, GSK872, orGSK-872) is a novel, potent and selective RIPK3 (receptor interacting protein kinase-3) inhibitor.
V32533	GSK-843	1601496-05-2	GSK-843 (GSK843) is a novel and potent inhibitot of receptor-interacting protein kinase 3 (RIP3 or RIPK3) with anti-inflammatory effects.
V41990	GSK-872 hydrochloride	2703752-81-0	GSK-872 hydrochloride (GSK872; GSK2399872A; GSK872; GSK-872) is a novel, potent and selective RIPK3 (receptor interacting protein kinase-3) inhibitor with anticancer and anti-inflammatory effects.
V3290	GSK-963	2049868-46-2	GSK-963 (also known as GSK963 or GSK963), is a potent and selectiveRIP1 kinase inhibitor.
V3532	GSK2593074A	1337531-06-2	GSK2593074A (also known as GSK’074) is a novel and potent necroptosisinhibitor with dual targeting ability to bothRIP1andRIP3.
V2776	GSK2982772	1622848-92-3	GSK2982772 (GSK-2982772; GSK772) is a potent, selective, oral and ATP competitive inhibitor of RIP1 (receptor Interacting Protein 1) with the potentialfor the treatment of inflammatory diseases.
V76955	GSK2983559		GSK2983559 (compound 3) is an orally bioactive and potent receptor-interacting protein 2 (RIP2) kinase inhibitor.
V6404	GSK2983559 active metabolite	1423186-80-4	GSK2983559active metabolite, formerly known as RIPK2-IN-1,is an active metabolite of GSK2983559which is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.
V34660	GSK2983559 free acid	1579965-12-0	GSK2983559 free acid (compound 3) is a potent, specific and oral bioactive receptor interacting protein 2 (RIP2) kinase inhibitor, showingexcellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
V32475	GSK3145095	1622849-43-7	GSK3145095 is a RIP1 kinase inhibitor (antagonist) with IC50 of 6.3 nM.
V3534	GSK481	1622849-58-4	GSK481 is a novel, potent and selective inhibitor of RIP1 (receptor interacting protein 1) WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.
V2059	GSK547	2226735-55-1	GSK547 (GSK547;GSK-547) is a novel, potent and highly selective inhibitor ofRIP1 (receptor-interacting serine/threonine protein kinase 1) with immunomodulatory effects.
V2611	GSK583	1346547-00-9	GSK583 is a highly potent and selective RIP2 kinaseinhibitor with an IC50 value of 5 nM.
V3954	HS1371	2158197-70-5	HS-1371is a novel, potent and ATP-competitiveRIP3 (receptor-interacting protein kinase 3) inhibitor that is identified by the extensive screening of chemical libraries focused on kinases.
V76915	HTH-01-091 TFA		HTH-01-091 TFA is a potent and specific inhibitor of maternal embryonic leucine zipper kinase (MELK) with IC50 of 10.5 nM.
V80791	MLKL-IN-4		MLKL-IN-4 (compound 56) is a potent inhibitor of MLKL (mixed lineage kinase domain-like protein).
V3292	Necrostatin 2 R-isomer	852391-19-6	Necrostatin 2 R-isomer is the R-enantiomer of Necrostatin 2 (also known asNecrostatin-2, Necrostatin-2 racemate, (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s) which is a potent necroptosis inhibitor with EC50 of 50 nM.
V29086	Necrostatin 2 S enantiomer	852391-20-9	Necrostatin 2 S-isomer is the S-enantiomer of Necrostatin 2 (also known asNecrostatin-2, Necrostatin-2 racemate, (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s) which is a potent necroptosis inhibitor with EC50 of 50 nM.