AP-1

AP-1

Activator Protein 1 (AP-1) is not a single protein, but a collective term referring to dimeric transcription factors composed of Jun (c-Jun, JunB, JunD), Fos (c-Fos, FosB, Fra-1, Fra-2) ATF (activating transcription factor, ATF-2, ATF-3/LRF1, ATF-4, ATF-5, ATF-6B, ATF-7, BATF, BATF-2, BATF-3, JDP2) or MAF (c-MAF, MafA, MafB, MafF, MafG, MafK and Nrl) subunits that bind to a common DNA site, the AP-1-binding site. Many different cellular and physiological processes involve AP-1.

It is acknowledged as a master integrator of a myriad of extracellular signals allowing cells to adapt to changes in their environment. AP-1 has also been implicated in various severe diseases. These include transplant rejection, fibrosis, organ injury and a variety of inflammatory pathologies such as rheumatoid arthritis, asthma and psoriasis. In addition, cancer is undoubtedly the most documented pathology involving AP-1 where its activity is often dysregulated and contributes to cell transformation, tumor progression, aggressiveness and resistance to treatments.

AP-1 related products

Structure Cat No. Product Name CAS No. Product Description
V51074 (+)-Glaucarubinone 1259-86-5 (+)-Glaucarubinone is a potent inhibitor of activator protein-1 (AP-1) with EC50 of 0.13 µM.
V51071 Chloranthalactone B 66395-03-7 Chloranthalactone B is an indanane-type sesquiterpenoid, a naturally occurring compound that can be extracted from Herba Coral by distillation.
V74744 Fas C-Terminal Tripeptide 189109-90-8 Fas C-Terminal Tripeptide is the C-terminal tripeptide of Fas protein.
V41511 SR-11302 160162-42-5 SR-11302 (SR11302) is an AP-1 (activator protein-1) transcription factor inhibitor withantitumor activity.
V2895 T-5224 530141-72-1 T-5224 is a novel and selective inhibitor of c-Fos/activator protein-1 (AP-1) which is a transcriptional factor that regulates the expression of various genes associated with tumor invasion and migration.
V51070 Timolumab (BTT-1023 ) 1073538-99-4 Timolumab (BTT1023) is a recombinant, fully human monoclonal that specifically binds VAP-1.
V51073 Vapaliximab 336801-86-6 Vapaliximab (2D10) is an anti-human VAP-1 monoclonal antibody (mAb).
V51069 Vepalimomab 195158-85-1 Vepalimomab (Anti-Human AOC3 Recombinant Antibody) is a monoclonal antibody (mAb) that blocks vascular adhesion protein 1 (VAP-1).
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