Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.
A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.
DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73083 | 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one | 1809980-25-3 | 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a naturally occurring compound found in the bark of M. |
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V77995 | Antidiabetic agent 2 | Antidiabetic agent 2 (Compound 56) is a glucose uptake enhancer. | |
|
V73071 | Azaleatin | 529-51-1 | Azaleatin is an O-methylated flavonol extracted from Rhododendron species. |
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V51751 | Begelomab (SAND-26) | 1403744-56-8 | Begelomab (SAND-26) is a mouse IgG2b monoclonal antibody (mAb) directed against DPP-4/CD26. |
|
V3984 | Brensocatib (AZD7986) | 1802148-05-5 | Brensocatib (formerly known asAZD-7986; INS-1007) is anovel, second generation, highly potent, covalent reversible, and selective DPP1 (Dipeptidyl peptidase 1) inhibitor with anti-COPD effects. |
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V2857 | DBPR108 | 1186426-66-3 | DBPR108 is a novel, potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; It shows no inhibition on DDP8 and DPP9. |
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V73079 | DPP IV/hCA II-IN-1 | 2836996-95-1 | DPP IV/hCA II-IN-1 is a potent and specific inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA). |
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V73076 | DPP1-IN-1 | 2762114-61-2 | DPP1-IN-1 (compound 1) is a potent DPP1 inhibitor. |
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V73069 | DPP1-IN-1 hydrate | 2971064-13-6 | DPP1-IN-1 hydrate is a DPP1 inhibitor (IC50= 1.6 nM). |
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V73075 | Fotagliptin (SAL067 free base) | 1312954-58-7 | Fotagliptin is a dipeptidyl peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). |
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V73072 | Fotagliptin benzoate (SAL067) | 1403496-40-1 | Fotagliptin benzoate is a dipeptidyl peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). |
|
V73070 | Gemigliptin tartrate (LC15-0444 tartrate) | 1374639-74-3 | Gemigliptin tartrate (LC15-0444 tartrate) is a selective, reversible, competitive dipeptidyl peptidase 4 (DPP-4) inhibitor (antagonist) with IC50 of 10.3 nM for human recombinant DPP-4. |
|
V73081 | Lys-Ala-pNA | 115846-24-7 | Lys-Ala-pNA is a hydrolytic substrate for dipeptidyl peptidase (DPP) II with a Km of 0.42 mM. |
|
V73078 | NVP-DPP728 dihydrochloride | 207556-62-5 | NVP-DPP728 di-HCl is a potent and specific inhibitor of dipeptidyl peptidase IV (DPP-IV) with a Ki of 11 nM. |
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V73077 | O-Benzoylhydroxylamine | 54495-98-6 | O-Benzoyloxyamine is a DPP-IV inhibitor (antagonist) with anti-diabetic effects (WO2006034435A2). |
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V73080 | P32/98 | 136259-20-6 | P32/98 is a dipeptidyl peptidase IV (DPP4) inhibitor. |
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V73073 | Sheng Gelieting (CGT-8012) | 1152810-23-5 | Sheng Gelieting (CGT-8012) is a dipeptidyl peptidase-IV enzyme (DP-IV) inhibitor. |
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V73074 | Sitagliptin fenilalanil hydrochloride | 1339954-75-4 | Sitagliptin fenilalanil HCl is a dipeptide aminopeptidase (DPP-4) inhibitor. |
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V29755 | Sitagliptin phosphate | 654671-78-0 | Sitagliptin phosphate (MK431; Januvia), thephosphate salt ofSitagliptin, is an antihyperglycemic agent (sugar-lowering) and antidiabetic medication that act as a potent inhibitor of DPP-IV (dipeptidyl peptidase-4) with IC50 of 19 nM in Caco-2 cell extracts. |
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V76456 | Talabostat isomer mesylate | Talabostat isomer mesylate is an isomer of talabostat mesylate. |
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