Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes aid in the metabolism of hydrogen peroxide and guard against oxidative damage to the structure and operation of cell membranes. Severe pathologies like diabetes and obesity are associated with dysregulated GPx expression. In various tumor models, GPx1 has been implicated in both pro- and anticancer effects.
Eight members of the GPxs family have been identified in mammals (GPx1–GPx8); five of them (GPx1–GPx4 and GPx6) have selenocysteine in their catalytic centers, while the other three are cysteine-containing proteins. One of the GPxs family members that is most important for catalytically reducing hydrogen peroxide to produce water is GPx1. The job of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to lessen chronic oxidative stress and to keep vascular nitric oxide bioavailable. Gpx4 is a crucial mammalian glutathione peroxidase that controls ferroptosis, a novel type of controlled necrotic cell death. It also safeguards cells against harmful lipid peroxidation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73802 | (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid | 771493-42-6 | (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is an α-Glucosidase ) inhibitor (antagonist) with IC50 of 577.7 µM. |
|
V73799 | (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) | 41607-20-9 | (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 48.13 µM. |
|
V73800 | (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid | 132282-70-3 | (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin extracted from Rubus ellipticus var. |
|
V73786 | 2-Nitrophenyl aD-glucopyranoside | 56193-44-3 | 2-Nitrophenyl aD-glucopyranoside is a beta-glucosidase substrate. |
|
V73808 | 2-Nitrophenyl β-D-glucopyranoside | 2816-24-2 | 2-Nitrophenyl β-D-glucopyranoside is a substrate of β-glucosidase. |
|
V73782 | 4-Methylumbelliferyl α-L-arabinofuranoside | 77471-44-4 | 4-Methylumbelliferyl α-L-arabinofuranoside is a substrate for glycosidases. |
|
V73777 | 4-Methylumbelliferyl β-D-Glucopyranoside | 18997-57-4 | 4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorescent substrate for β-glucosidase and is used to measure β-glucosidase activity. |
|
V73779 | 4-Nitrophenyl aD-glucopyranoside | 3767-28-0 | 4-Nitrophenyl aD-glucopyranoside is a chromogenic substrate for α-glucosidase. |
|
V73818 | 5-O-Methylgenistein (Isoprunetin) | 4569-98-6 | 5-O-Mmethylgenistein (Isoprunetin) is an isoflavone that can be extracted from M. |
|
V73814 | 6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone | 1622982-59-5 | 6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone (compound 1) is an anthraquinone α-glucosidase inhibitor (IC50= 185 μM), which can be extracted from Cassia seeds. |
|
V73813 | 6-Prenylquercetin-3-Me ether | 151649-34-2 | 6-Prenylquercetin-3-Me ether is a naturally occurring compound that can be found in the leaves of G.uralensis. |
|
V73804 | 6β-Hydroxyipolamiide | 87797-84-0 | 6β-Hydroxyipolamiide can be extracted from the methanolic extract of S. jamaicensis leaves. |
|
V4241 | AZD-5904 | 618913-30-7 | AZD5904 is a novel,potent, orally bioavailable, irreversible inhibitor of human MPO (Myeloperoxidase) with an IC50 of 140 nM and with similar potency in mouse and rat. |
|
V73161 | Barbinervic acid | 64199-78-6 | Barbinervic acid is a glutaminase inhibitor (antagonist) with IC50 of 14 μM. |
|
V73795 | Bisabolone oxide A | 22567-38-0 | Bisabolone oxide A is an inhibitor (blocker/antagonist) of alpha-glucose. |
|
V73793 | Carpachromene | 57498-96-1 | Carpachromene is a potent α-glucosidase enzyme inhibitor. |
|
V73774 | Casuarictin | 79786-00-8 | Casuarictin is a potent and competitive α-glucosidase inhibitor (antagonist) with IC50 of 0.21 μg/mL. |
|
V73790 | Clervonafusp alfa (VAL-1221) | 2145123-44-8 | Clervonafusp alfa (VAL-1221) is a fusion protein targeting cytosolic and lysosomal glycogen. |
|
V73789 | Cyclophellitol aziridine | 136861-97-7 | Cyclophellitol aziridine is a cyclophenol analog and a potent β-glucosidase inhibitor. |
|
V73807 | EB-0150 | 2832824-40-3 | EB-0150 is a potent inhibitor of ER α-glucosidase (α-Glu) I and II, with IC50s values of 0.73 and less than 0.0337 μM, respectively. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
