Xanthine oxidase (XO), a multifunctional molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and then the subsequent reduction of oxygen at the flavin center with the production of reactive oxygen species, either superoxide anion radicals or hydrogen peroxide.
The purine catabolism pathway's key enzyme, xanthine oxidase, has been linked indirectly to a number of pathological conditions, including cancer, diabetes, and metabolic syndrome, as well as directly to the pathogenesis of gout. Gout, cancer, inflammation, and oxidative damage may all be treated therapeutically by selectively inhibiting xanthine oxidase.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71967 | 7,8,3′,4′-Tetrahydroxyflavone | 3440-24-2 | 7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor (antagonist) with IC50 of 10.488 µM. |
|
V71969 | Aurantiamide benzoate | 150881-02-0 | Aurantiamide benzoate is a naturally occurring compound extracted from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. |
|
V71981 | Baicalein 6-O-glucoside | 28279-72-3 | Baicalein 6-O-glucoside is the glucuronidation metabolite of Baicalein. |
|
V2072 | Febuxostat (TEI 6720; TMX 67) | 144060-53-7 | Febuxostat (formerly also called TMX 67, TEI-6720; TEI 6720; Uloric; TMX-67)is a potent and selective xanthine oxidase inhibitor with Ki of 0.6 nM and has been used to treat hyperuricemia and chronic gout. |
|
V71978 | URAT1&XO inhibitor 1 | 2669726-78-5 | URAT1&XO inhibitor 1 (compound 29) is a dual (bifunctional) inhibitor of URAT1 (IC50=~10μM) and xanthine oxidase (IC50=1.01μM). |
|
V80852 | Xanthine oxidase-IN-11 | Xanthine oxidase-IN-11 (XO8 analog) is a xanthine oxidase (XO) inhibitor. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
