HSP

HSP

Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.

HSP related products

Structure Cat No. Product Name CAS No. Product Description
V0874 17-DMAG (Alvespimycin) HCl 467214-21-7 17-DMAG (Alvespimycin, NSC-707545, BMS-826476 HCl, KOS-1022) HCl, the hydrochloride salt of17-DMAG, is a novel and potent HSP90 (heat shock protein 90) inhibitor with potential antineoplastic activity.
V0877 BIIB021 848695-25-0 BIIB021 (CNF2024;BIIB-021; CNF-2024; CNF 2024; BIIB 021) is an orally bioavailable and purine-based small-molecule inhibitor of HSP90 (heat shock protein 90) with potential anticancer activity.
V0883 CH5138303 959763-06-5 CH5138303 (CH 5138303; CH-5138303) is a novel, potent, orally boavailable HSP90 (Heat Shock Protein 90) inhibitor with potential anticancer activity.
V0876 Elesclomol (STA-4783) 488832-69-5 Elesclomol (STA4783; STA-4783;STA4783) is a bis(thio-hydrazide amide)-basedheat shock protein 70/HSP70induceras well as anoxidative stress inducer with potential antitumor and pro-apoptotic activity.
V0875 Ganetespib (STA-9090) 888216-25-9
V0891 Geldanamycin 30562-34-6 Geldanamycin (U-29135;NSC-122750; NSC122750; U 29135) isa natural occurring, benzoquinone-based ,19-membered macrocyle ansamycin class of anticancer antibiotic.
V0881 HSP990 (NVP-HSP990) 934343-74-5 NVP-HSP990 (NVP HSP 990; NVP-HSP-990;HSP990; HSP-990) is an orally bioavailableHSP90 (heat shock protein 90) inhibitor with potential antitumor activity.
V0880 KNK437 218924-25-5 KNK437 (KNK-437; KNK 437; Heat Shock Protein Inhibitor I), abenzylidene lactam analog, is a novel and potentpan-HSP (heat shock proteins) inhibitor with potential antineoplastic activity.
V0889 KW-2478 819812-04-9 KW-2478 (KW 2478;KW2478) is a nonansamycin inhibitor of HSP90(Heat Shock Protein 90) with potential antitumor activity.
V0873 Luminespib 747412-49-3 Luminespib (also known as NVP AUY922;NVP AUY-922; AUY922; AUY-922;VER52296;VER-52296),a 4,5-diarylisoxazole derivative, is a 3rd generation HSP90 (heat shock protein 90) inhibitorwith potential anticancer activity.
V0884 NMS-E973 1253584-84-7 NMS-E973 (NMSE973; NMSE 973) is a novel, potent and selective HSP90 (Heat Shock Protein 90) inhibitor with potential antitumor activity.
V5223 NPX800 1693734-80-3 NXP-800 (also known asDEL22379; DEL-22379) is a potentERK dimerization inhibitor andheat shock factor 1 (HSF1)inhibitor with anticancer effects.
V0892 NVP-BEP800 847559-80-2 NVP-BEP800 (VER-82576; NVP BEP-800; BEP-800) is a novel, potent, fully synthetic, orally bioavailable heat shock protein 90β (HSP90β)inhibitor with potential antitumor activity.
V0878 Onalespib (AT13387) 912999-49-6 Onalespib (formerly AT13387; AT-13387; AT 13387) is a novel, orally bioavailable,long-acting and isoindole-based small-molecule HSP90 (heat shock protein 90) inhibitor with potential antitumor activity.
V0890 PF-04929113 (SNX-5422) 908115-27-5 PF-04929113 (SNX-5422;PF04929113; PF-4929113) is a potent and selective inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity.
V0888 SNX-2112 (PF-04928473) 908112-43-6 SNX-2112 (SNX2112; SNX 2112;PF-04928473; PF04928473)is a novel and potent HSP90(Heat Shock Protein 90) with potential antitumor activity and was inphase 1 clinical trials.
V0872 Tanespimycin (17-AAG) 75747-14-7 Tanespimycin (formerly NSC-330507; CP-127374; 17-AAG,BAY-579352,KOS-953,17-AAG,CP-127374),a benzoquinone analog and a derivative of the antibiotic geldanamycin,is an orally bioavailable and small-molecule inhibitor of heat shock protein 90/HSP90 with potential antitumor activity.
V2769 TRC051384 867164-40-7 TRC051384 is a novel compoundwhich can potently induce HSPA1A/B (heat shock protein) expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation.
V0886 VER-49009 558640-51-0 VER-49009 (CCT0129397;VER 49009; CCT-0129397; VER49009), apyrazole-based compound,is a novel, potent and selective inhibitor of HSP90 (Heat Shock Protein 90) with potential antitumor activity.
V0882 VER-50589 747413-08-7 VER-50589 (VER 50589; VER50589) is a highly potent and selectiveHSP90 (Heat Shock Protein 90) inhibitor with potential antineoplastic activity.
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