Protein kinase C (PKC) is a family of protein kinase enzymes that play a role in regulating the activity of other proteins by phosphorylating the hydroxyl groups on serine and threonine amino acid residues. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes are crucial components of numerous signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V30832 | Chelerythrine | 34316-15-9 | Chelerythrine is a naturally occurring alkaloid that is a potent and specific Ca2+/phospholipid-dependent PKC antagonist (inhibitor) with IC50 of 0.7 μM. |
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V3977 | CHELERYTHRINE CHLORIDE | 3895-92-9 | Chelerythrine chloride (NSC-36405; NSC36405), a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus), is a potent, cell-permeable, selective protein kinase C inhibitorwith anIC50of 660 nM. |
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V4878 | CMPD-101 | 865608-11-3 | CMPD101 is a novel, potent and selective inhibitor of G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) with IC50 values of 35 and 32 nM for GRK2 and GRK3, respectively. |
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V33467 | D-erythro-Sphingosine (Erythrosphingosine) | 123-78-4 | D-erythro-Sphingosine(Erythrosphingosine) is a highly potent activator of p32-kinase with an EC50 of 8 μM. |
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V3649 | Darovasertib (LXS-196; IDE-196) | 1874276-76-2 | Darovasertib (LXS196; IDE196) is a novel, potent, selective and orally bioactive inhibitor of protein kinase C (PKC)with anticancer activity. |
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V12078 | Ingenol | 30220-46-3 | Ingenol is a PKC activator with Ki of 30 μM and anti-tumor activity. |
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V40351 | N-Desmethyltamoxifen HCl | 15917-65-4 | N-Desmethyltamoxifen HCl is the major metabolite of Tamoxifen in the human body. |
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V25817 | Phorbol 12,13-dibutyrate | 37558-16-0 | Phorbol 12,13-dibutyrate (PDBu; Phorbol dibutyrate) is a phorbol ester acting as a PKC activator and a potent skin tumor promoter. |
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V67538 | PKC beta pseudosubstrate | 172308-76-8 | PKC β pseudosubstrate is a selective, cell-penetrable PKC inhibitor. |
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V2030 | PKC-theta inhibitor | 736048-65-0 | PKC-theta inhibitor is a novel, potent and selective PKC-θ inhibitor with anIC50of 12 nM. |
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V25200 | PKC-theta inhibitor hcl | 2253640-49-0 | PKC-theta inhibitor HCl is a novel and potent PKC-θ inhibitor |
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V27043 | PKCß inhibitor | 257879-35-9 | PKCß inhibitor, ananilino-monoindolylmaleimide compound, is a novel, potent,ATP-competitive and selective inhibitor of PKCß isozymes. |
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V67537 | PKCβII Peptide Inhibitor I | 862502-26-9 | PKCβII Peptide Inhibitor I is a PKCβII inhibitor. |
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V67539 | PKCδ Peptide Substrate | 813416-46-5 | PKCδ Peptide Substrate is an absolutely specific substrate for δ-type PKC, and its sequence corresponds to the mouse eEF-1α sequence 422-443 containing Thr-431. |
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V67535 | PKCε (85-92) | 207111-98-6 | PKCε (85-92) is a biologically active peptide. |
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V67536 | PKCη pseudosubstrate inhibitor,myristoylated | 908012-19-1 | PKCη pseudosubstrate inhibitor, myristoylated is cell permeable/penetrable and may be utilized to study the mechanism of action of PKCη. |
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V13120 | Protein kinase inhibitor H-7 | 84477-87-2 | Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide-dependent protein kinase, with Ki of 6 μM for PKC inhibition. |
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V7780 | R59022 | 93076-89-2 | R59022 (R-59022; DKGI-I) is a novel and potent DGKalpha inhibitor and serotonin receptor antagonist. |
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V8973 | Ruboxistaurin (LY333531) | 169939-94-0 | Ruboxistaurin (LY-333531; LY333531)is a novel, potent and specific inhibitor of PKCβ (protein kinase C) with potential antidiabetic activity. |
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V2574 | Ruboxistaurin hydrochloride (LY333531) | 169939-93-9 | Ruboxistaurin HCl, the hydrochloride salt ofRuboxistaurin (LY-333531; LY333531), is a novel, potent and specific inhibitor of PKCβ (protein kinase C) with diabetic effects. |
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