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Signaling Pathways
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Cell Cycle
Signaling Pathways
Apoptosis
♦
Bcl-2
(
11
)
♦
p53
(
11
)
♦
Caspase
(
10
)
♦
TNFa
(
4
)
♦
Mdm2
(
15
)
♦
c-RET
(
4
)
♦
IAP
(
6
)
♦
PERK
(
4
)
♦
PD-1/PD-L1
(
11
)
♦
Survivin
(
1
)
PI3K/Akt/mTOR
♦
PI3K
(
62
)
♦
Akt
(
18
)
♦
mTOR
(
21
)
♦
GSK-3
(
17
)
♦
ATM/ATR
(
0
)
♦
PDK-1
(
4
)
♦
S6 kinase
(
6
)
♦
AMPK
(
8
)
♦
DNA-PK
(
3
)
Epigenetics
♦
HDAC
(
2
)
♦
HIF
(
8
)
♦
PARP
(
0
)
♦
JAK
(
33
)
♦
Aurora Kinase
(
23
)
♦
Histone Acetyltransferase
(
6
)
♦
Histone Demethylase
(
9
)
♦
Histone Methyltransferase
(
26
)
♦
DNA Methyltransferase
(
8
)
♦
Epigenetic Reader Domain
(
19
)
♦
Sirtuin
(
11
)
♦
Pim
(
6
)
MAPK
♦
MEK
(
18
)
♦
ERK
(
8
)
♦
Raf
(
15
)
♦
JNK
(
7
)
♦
p38 MAPK
(
13
)
Protein Tyrosine Kinase
♦
VEGFR
(
46
)
♦
EGFR
(
40
)
♦
PDGFR
(
11
)
♦
c-MET
(
14
)
♦
HER-2
(
2
)
♦
ALK
(
10
)
♦
FLT3
(
8
)
♦
FGFR
(
10
)
♦
IFG-1R
(
8
)
♦
c-Kit
(
3
)
♦
Tie-2
(
1
)
♦
CSF-1R
(
2
)
♦
TAM Receptor
(
6
)
♦
Trk receptor
(
3
)
♦
c-RET
(
0
)
Angiogenesis
♦
VEGFR
(
1
)
♦
EGFR
(
0
)
♦
PDGFR
(
0
)
♦
HIF
(
0
)
♦
HER-2
(
0
)
♦
JAK
(
0
)
♦
FLT3
(
0
)
♦
FGFR
(
0
)
♦
BTK
(
7
)
♦
Syk
(
6
)
♦
FAK
(
8
)
♦
Src
(
8
)
♦
Bcr-Abl
(
10
)
♦
VDA
(
3
)
Proteases
♦
Proteasome
(
13
)
♦
Cysteine Protease
(
11
)
♦
Serine Protease
(
5
)
♦
Gamma-secretase
(
10
)
♦
HCV Protease
(
5
)
♦
HIV Protease
(
7
)
♦
MMP
(
6
)
♦
DPP-4
(
8
)
♦
Caspase
(
0
)
NF-kB
♦
NOD1
(
2
)
♦
IκB/IKK
(
14
)
♦
NF-κB
(
6
)
♦
HDAC
(
0
)
Autophagy
♦
Autophagy
(
20
)
♦
LRRK2
(
5
)
JAK/STAT
♦
JAK
(
1
)
♦
STAT
(
0
)
♦
EGFR
(
0
)
♦
Pim
(
0
)
Metabolism
♦
PDE
(
26
)
♦
P450 (e.g. CYP)
(
24
)
♦
PPAR
(
16
)
♦
Phospholipase
(
7
)
♦
DHFR
(
5
)
♦
Dehydrogenase
(
19
)
♦
HSP
(
20
)
♦
Carbonic Anhydrase
(
16
)
♦
MAO
(
0
)
♦
FAAH
(
5
)
♦
CETP
(
4
)
♦
Transferase
(
8
)
♦
HMG-CoA Reductase
(
11
)
♦
Hydroxylase
(
8
)
♦
IDO
(
4
)
♦
Retinoid Receptor
(
5
)
♦
Factor Xa
(
4
)
♦
AhR
(
3
)
♦
Ferroptosis
(
3
)
♦
Casein Kinase
(
4
)
♦
NAMPT
(
3
)
Neuronal Signaling
♦
5-HT Receptor
(
0
)
♦
COX
(
40
)
♦
GluR
(
16
)
♦
Adrenergic Receptor
(
0
)
♦
AChR Receptor
(
47
)
♦
Histamine Receptor
(
0
)
♦
Dopamine Receptor
(
0
)
♦
Opioid Receptor
(
0
)
♦
GABA Receptor
(
0
)
♦
P-gp
(
0
)
♦
CaMK
(
8
)
♦
P2 Receptor
(
7
)
♦
OX Receptor
(
0
)
♦
MT Receptor
(
0
)
♦
BACE
(
2
)
♦
Gamma-secretase
(
0
)
♦
Beta Amyloid
(
1
)
Ubiquitin
♦
E2 conjugating
(
1
)
♦
p97
(
3
)
♦
E3 Ligase
(
0
)
♦
DUB
(
8
)
♦
Proteasome
(
0
)
Stem Cells/Wnt
♦
Hedgehog/Smoothened ROCK
(
0
)
♦
ROCK
(
0
)
♦
Wnt/beta-catenin
(
0
)
♦
Gamma-secretase
(
0
)
♦
Casein Kinase
(
0
)
♦
TGF–beta/Smad
(
0
)
♦
STAT
(
9
)
♦
JAK
(
0
)
♦
GSK-3
(
0
)
DNA Damage
♦
Telomerase
(
2
)
♦
Topoisomerase
(
36
)
♦
DNA/RNA Synthesis
(
65
)
♦
HDAC
(
38
)
♦
ATM/ATR
(
14
)
♦
PARP
(
28
)
♦
Sirtuin
(
0
)
GPCR & G Protein
♦
cAMP
(
1
)
♦
Adenosine Receptor
(
4
)
♦
Vasopressin Receptor
(
3
)
♦
CXCR
(
3
)
♦
CaSR
(
2
)
♦
PAFR
(
2
)
♦
CGRP Receptor
(
1
)
♦
LPA Receptor
(
2
)
♦
SGLT
(
4
)
♦
S1P Receptor
(
7
)
♦
Endothelin Receptor
(
7
)
♦
Cannabinoid Receptor
(
7
)
♦
5-HT Receptor
(
63
)
♦
Adrenergic Receptor
(
65
)
♦
Histamine Receptor
(
41
)
♦
Dopamine Receptor
(
28
)
♦
Opioid Receptor
(
9
)
♦
Hedgehog/Smoothened ROCK
(
11
)
♦
OX Receptor
(
7
)
♦
MT Receptor
(
2
)
TGF-beta/Smad
♦
MT Receptor
(
20
)
♦
Bcr-Abl
(
0
)
♦
ROCK
(
20
)
♦
PKC
(
9
)
Cell Cycle
♦
CDK
(
38
)
♦
Rho
(
13
)
♦
PLK
(
10
)
♦
Chk
(
6
)
♦
Aurora Kinase
(
0
)
♦
ROCK
(
0
)
♦
PD-1/PD-L1
(
0
)
♦
c-Myc
(
2
)
♦
Wee1
(
1
)
♦
APC
(
1
)
Cytoskeletal Signaling
♦
Bcr-Abl
(
1
)
♦
Wnt/beta-catenin
(
10
)
♦
PKC
(
0
)
♦
FAK
(
0
)
♦
HSP
(
0
)
♦
Dynamin
(
3
)
♦
PAK
(
3
)
♦
Integrin
(
8
)
♦
Microtubule Associated
(
24
)
♦
Kinesin
(
6
)
Transmembrane
♦
P-gp
(
6
)
♦
Proton Pump
(
10
)
♦
GABA Receptor
(
11
)
♦
Sodium Channel
(
27
)
♦
Potassium Channel
(
16
)
♦
Calcium Channel
(
33
)
♦
ATPase
(
0
)
♦
CRM1
(
1
)
♦
TRPV
(
0
)
♦
CFTR
(
0
)
♦
OCT
(
0
)
Endocrinology & Hormones
♦
Opioid Receptor
(
0
)
♦
Glucocorticoid Receptor
(
5
)
♦
Estrogen/progestogen Receptor
(
34
)
♦
Androgen Receptor
(
13
)
♦
RAAS
(
27
)
♦
Aromatase
(
5
)
♦
GPR
(
5
)
♦
5-alpha Reductase
(
2
)
Microbiology
♦
HCV Protease
(
0
)
♦
HIV Protease
(
0
)
♦
CCR
(
1
)
♦
Reverse Transcriptase
(
27
)
♦
Integrase
(
0
)
Others
♦
gp120/CD4
(
2
)
♦
FXR
(
4
)
♦
PKA
(
2
)
♦
Thrombin
(
4
)
♦
Liver X receptor
(
3
)
♦
IL Receptor
(
0
)
♦
Others 1
(
359
)
♦
Others 2
(
433
)
♦
Others 3
(
331
)
♦
Others 4
(
296
)
♦
Others 5
(
250
)
♦
Others 6
(
292
)
♦
Others 7
(
229
)
New Products
♦
New1
(
25745
)
♦
New2
(
6781
)
♦
New3
(
859
)
Product Type
Natural Products
♦
Natural Products 1
(
443
)
Peptides
♦
Peptides 1
(
1957
)
Antibodies
Amino Acids
♦
Amino Acids 1
(
384
)
PROTACs
♦
PROTACs 1
(
29
)
Fine Intermediates/Building Blocks
Others
Senexin A
Catalog No：
V2743
CAS No. (CAS Registry Number)：
1366002-50-7
Price：
$0/g
Description: Senexin A is a novel, potent, selective and ATP site competitive inhibitor of CDK8 and CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19, respectively....
Prexasertib (LY2606368)
Catalog No：
V2744
CAS No. (CAS Registry Number)：
1234015-52-1 (free base)
Price：
$0/g
Description: Prexasertib (also known as LY2606368) is a novel, potent, selective and ATP competitive inhibitor of the CHK1 (checkpoint kinase 1) protein kinase with IC50&...
ARS-853
Catalog No：
V2745
CAS No. (CAS Registry Number)：
1629268-00-3
Price：
$0/g
Description: ARS-853 is a novel, potent, selective, and covalent inhibitor of KRAS(G12C) with IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the ...
Zotiraciclib (TG-02, SB-1317)
Catalog No：
V7667
CAS No. (CAS Registry Number)：
1204918-72-8
Price：
$0/g
Description: Zotiraciclib (formerly TG02, SB1317) is an orally bioavailable, brain penetrant and multi-kinase (CDK/JAK2/FLT3) inhibitor for the treatment of cancer (e.g. anaplastic ast...
Zotiraciclib diHCl (TG-02, SB-1317)
Catalog No：
V7904
CAS No. (CAS Registry Number)：
1354567-82-0
Price：
$0/g
Description: Zotiraciclib diHCl (formerly TG02, SB1317) is an orally bioavailable, brain penetrant and multi-kinase (CDK/JAK2/FLT3) inhibitor for the treatment of cancer (e.g. anaplast...
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