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    Catalog No: V1331
    CAS No. (CAS Registry Number): 879085-55-9
    Description: Vismodegib (formerly known as GDC-0449 or RG3616; trade name: Erivedge) is a potent, orally bioavailable, first-in-class and specific hedgehog inhibitor with IC50 of 3 nM and also inhibit...
    Catalog No: V1332
    CAS No. (CAS Registry Number): 4449-51-8
    Description: Cyclopamine (also known as 11-deoxojervine) is a potent and specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells. Cyclopamine is a n...
    Catalog No: V1333
    CAS No. (CAS Registry Number): 956697-53-3 (free base)
    Description: LDE225 (also known as NVP-LDE225, Erismodegib, Sonidegib; trade name of Odomzo) is an orally bioavailable small-molecule antagonist of the Smoothened (Smo) which inhibits the Hedgeho...
    Catalog No: V1334
    CAS No. (CAS Registry Number): 1258861-20-9
    Description: Taladegib (formerly also known as LY2940680) is a novel and potent antagonist of the smoothened receptor. It binds to the Smoothened (Smo) receptor and potently inhibits Hedgeho...
    Catalog No: V1335
    CAS No. (CAS Registry Number): 483367-10-8
    Description: Purmorphamine (Shh Signaling Antagonist VI) is a potent smoothened receptor agonist (EC50 = 1 μM) that directly binds and activates Smoothened, blocks BODIPY-cyclopami...
    Catalog No: V1336
    CAS No. (CAS Registry Number): 1373615-35-0
    Description: PF-5274857 is a novel, potent, orally bioactive and selective Smoothened (Smo) antagonist, it inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively. PF...
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