Xylazine HCl (BAY 1470 HCl)

Alias: BAY-VA 1470; BAY1470; Anased; BAY 1470; BAY-1470; Xylazine hydrochloride; Primazine; Rometar; Sedomin; WH 7286; Xilazina
Cat No.:V1080 Purity: ≥98%
Xylazine HCl (Anased; BAY 1470; BAY-1470; Primazine; Rometar; Sedomin; WH-7286; Xilazina), the hydrochloride salt of xylazine and an analogue of clonidine,is an α2-Adrenergic receptor agonist that has been approved as aVeterinarian drug and used for sedation, muscle relaxation,anesthesia, and analgesia in big animals such as horses, cattles and other non-human mammals.
Xylazine HCl (BAY 1470 HCl) Chemical Structure CAS No.: 23076-35-9
Product category: Adrenergic Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
250mg
500mg
1g
2g
5g
10g
Other Sizes

Other Forms of Xylazine HCl (BAY 1470 HCl):

  • Xylazine
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Xylazine HCl (Anased; BAY 1470; BAY-1470;Primazine; Rometar; Sedomin; WH-7286; Xilazina), the hydrochloride salt of xylazine and an analogue of clonidine, is an α2-Adrenergic receptor agonist that has been approved as a Veterinarian drug and used for sedation, muscle relaxation, anesthesia, and analgesia in big animals such as horses, cattles and other non-human mammals. Veterinarians additionally use xylazine as an emetic, particularly for cats. When naloxine is present, Xylazine significantly prolongs the analgesic effects in 40 and 50 minutes, according to analgesic testing.

Biological Activity I Assay Protocols (From Reference)
Targets
α2-adrenergic
ln Vitro

ln Vivo
Xylazine dose-dependently inhibits lipolysis and norepinephrine release in beagle dogs. Additionally, xylazine has a dose-dependent tendency to lower adrenaline levels. In horses, the minimum alveolar concentration (MAC) is decreased in a dose- and time-dependent manner by xylazine hydrochloride[1]. Horse blood glucose levels are dose- and time-dependently increased by xylazine hydrochloride.[2] In standing mares, xylazine produces variable bilateral caudal analgesia from the coccyx to the S3, along with ataxia, minimal sedation, and depression of the cardiovascular and respiratory systems. Heart and respiratory rates, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport are all markedly reduced by xylazine. Systolic, diastolic, and mean arterial blood pressure are also significantly reduced.[3] In horses, xylazine causes a marked reduction in heart rate, an increase in atrioventricular block incidence, and a decrease in cardiac output and cardiac index.[4] For a minimum of two hours, xylazine causes sedation and selective (S3 to Co) analgesia in cows. In cows, xylazine significantly raises base excess, bicarbonate concentration, and PaCO2 while significantly lowering heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration.[5] In the nonanesthetized, decerebrated rat, xylazine completely eliminates the climbing fiber field (-100%) and severely depresses the N3 field (-75%). In the nonanesthetized, decerebrated rat, xylazine-ketamine injections also significantly reduce the N3 field (-75%) and almost totally eliminate the climbing fiber field (-90%).[6]
Animal Protocol
0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl; epidural injection
Horse
References

[1]. Can J Vet Res . 2002 Jan;66(1):42-9.

[2]. Am J Vet Res . 2000 Oct;61(10):1225-31.

[3]. Am J Vet Res . 1996 Feb;57(2):193-200.

[4]. Am J Vet Res . 1991 May;52(5):651-7.

[5]. Am J Vet Res . 1990 Aug;51(8):1232-6.

[6]. J Neurophysiol . 2007 Sep;98(3):1697-705.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C12H17CLN2S
Molecular Weight
256.79
Exact Mass
256.08
Elemental Analysis
C, 56.13; H, 6.67; Cl, 13.80; N, 10.91; S, 12.48
CAS #
23076-35-9
Appearance
Solid powder
SMILES
CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl
InChi Key
QYEFBJRXKKSABU-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
Chemical Name
N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;hydrochloride
Synonyms
BAY-VA 1470; BAY1470; Anased; BAY 1470; BAY-1470; Xylazine hydrochloride; Primazine; Rometar; Sedomin; WH 7286; Xilazina
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 50~51 mg/mL (194.7~198.6 mM)
Water: ~12 mg/mL (~46.7 mM)
Ethanol: ~50 mg/mL (~194.7 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.8942 mL 19.4712 mL 38.9423 mL
5 mM 0.7788 mL 3.8942 mL 7.7885 mL
10 mM 0.3894 mL 1.9471 mL 3.8942 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Biological Data
  • Effects on the N3 field of ketamine, xylazine, and ketamine + xylazine. J Neurophysiol . 2007 Sep;98(3):1697-705.
  • Repeated injections of ketamine and xylazine. J Neurophysiol . 2007 Sep;98(3):1697-705.
  • Plasma glucose levels following the administration of medetomidine (MED μg/kg, A) and xylazine (XYL mg/kg, B) in dogs. Can J Vet Res . 2002 Jan;66(1):42-9.
  • The normalised AUC (0–8 h) data of the plasma glucose graphs are plotted versus the dose of medetomidine (A) and xylazine (B). Can J Vet Res . 2002 Jan;66(1):42-9.
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