| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
It has been demonstrated that the acid-activated detergent N-dodecylimidazole, which has a pKa of 6.3, is cytotoxic to cultured cells. On EMT-6 and MGH U1 cells, N-docecylimidazole exhibited cytotoxicity that was dependent on extracellular pH (pHe). Cell death is 100 times more common at pH 6.0 than pH 7.0 and is dose-dependent [4].
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|---|---|
| ln Vivo |
The inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase contributes to 1-dodecylimidazole's ability to decrease cholesterol [2]. 1. Rats given dodecylimidazole (150 mg/kg body weight; given daily for 10 days via gastric tube) had lower serum cholesterol concentrations than control rats [2].
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| Animal Protocol |
Animal/Disease Models: Male rats[2]
Doses: 150 mg/kg body wt Route of Administration: By stomach tube; daily for 10 days Experimental Results: Had Dramatically lower serum cholesterol concentrations than untreated animals. |
| References |
|
| Molecular Formula |
C15H28N2
|
|---|---|
| Molecular Weight |
236.40
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| Exact Mass |
236.225
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| CAS # |
4303-67-7
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| PubChem CID |
78002
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| Appearance |
Colorless to light yellow liquid
|
| LogP |
4.804
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
17
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| Complexity |
159
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| Defined Atom Stereocenter Count |
0
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| SMILES |
N1(C=NC=C1)CCCCCCCCCCCC
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| InChi Key |
JMTFLSQHQSFNTE-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H28N2/c1-2-3-4-5-6-7-8-9-10-11-13-17-14-12-16-15-17/h12,14-15H,2-11,13H2,1H3
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| Chemical Name |
1-dodecylimidazole
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : 100 mg/mL (423.01 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.58 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (10.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2301 mL | 21.1506 mL | 42.3012 mL | |
| 5 mM | 0.8460 mL | 4.2301 mL | 8.4602 mL | |
| 10 mM | 0.4230 mL | 2.1151 mL | 4.2301 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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