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Both ER-associated degradation (ERAD) and autophagy play crucial roles in maintaining ER protein homeostasis.

Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals with worldwide contamination and human exposure.

The invasion of human embryos in the uterus overcoming the maternal tissue barrier is a crucial step in embryo implantation and subsequent development.

Background: Langerhans cells (LC) are epidermal dendritic cells building the skin's outermost immunological barrier and bridging innate and adaptive immune responses.

Loss-of-function mutations in the PINK1 and PRKN genes are the most common cause of early-onset Parkinson disease (PD).

Germline mutations in the tumor suppressor TP53 lead to cancer predisposition, as seen in Li-Fraumeni syndrome (LFS).

Combination therapy, which involves the use of multiple drugs, has emerged as a promising approach to cancer treatment.

The ubiquitin kinase and ligase PINK1 and PRKN together label damaged mitochondria for their elimination in lysosomes by selective autophagy (mitophagy).

Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing, and the abnormal plasticity of SCs would jeopardize the bone regeneration.