| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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Description: Duvoglustat (Moranoline; deoxynojirimycin; 1-Deoxynojirimycin; AT-2220; DNJ) is a novel and potent alpha-glucosidase inhibitor found in mulberry leaves and has antihyperglycemic, anti-obesity, and antiviral activities. Duvoglustat can suppress the elevation of postprandial hyperglycemia, thus acting as an antihyperglycemic agent by slowing the rate of carbohydrate degradation to monosaccharides. 1-Deoxynojirimycin is most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillusspecies.
| ln Vivo |
1-Deoxynojirimycin (Duvoglustat) (20 -80 mg/kg; iv; once daily for 4 weeks) has consequences that are antiphysiological [3]. 1-Deoxynojirimycin enhances insulin symptoms noticeably by triggering the db/db shark shark pattern.
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| Animal Protocol |
Animal/Disease Models: db/db mice[3]
Doses: 20, 40, 80 mg/kg Route of Administration: intravenous (iv) (iv)injection; signal load PI3K/AKT[ 3]. one time/day for four weeks Experimental Results: Significant reduction in body weight, blood glucose, and serum insulin levels; improved glucose tolerance and insulin tolerance. |
| References |
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| Additional Infomation |
Duvoglustat is an optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an anti-HIV agent, an anti-obesity agent, a bacterial metabolite, a hypoglycemic agent, a hepatoprotective agent and a plant metabolite. It is a 2-(hydroxymethyl)piperidine-3,4,5-triol and a piperidine alkaloid.
An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. 1-Deoxynojirimycin has been reported in Parmotrema austrosinense, Parmotrema praesorediosum, and other organisms with data available. An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. See also: Fagomine (annotation moved to). |
| Molecular Formula |
C₆H₁₃NO₄
|
|---|---|
| Molecular Weight |
163.17
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| Exact Mass |
163.084
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| Elemental Analysis |
C, 44.17; H, 8.03; N, 8.58; O, 39.22
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| CAS # |
19130-96-2
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| Related CAS # |
1-Deoxynojirimycin hydrochloride;73285-50-4
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| PubChem CID |
29435
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
361.1±42.0 °C at 760 mmHg
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| Melting Point |
195-196°C
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| Flash Point |
197.3±18.5 °C
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| Vapour Pressure |
0.0±1.8 mmHg at 25°C
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| Index of Refraction |
1.582
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| LogP |
-2.1
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
11
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| Complexity |
132
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| Defined Atom Stereocenter Count |
4
|
| SMILES |
O([H])[C@@]1([H])[C@@]([H])([C@]([H])(C([H])([H])N([H])[C@]1([H])C([H])([H])O[H])O[H])O[H]
|
| InChi Key |
LXBIFEVIBLOUGU-JGWLITMVSA-N
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| InChi Code |
InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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| Chemical Name |
(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol
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| Synonyms |
BAY-h5595 DuvoglustatBAY-h-5595 1-deoxynojirimycinBAY-h 5595
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 34 mg/mL (~208.37 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (612.86 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.1286 mL | 30.6429 mL | 61.2858 mL | |
| 5 mM | 1.2257 mL | 6.1286 mL | 12.2572 mL | |
| 10 mM | 0.6129 mL | 3.0643 mL | 6.1286 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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