| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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| ln Vitro |
3'-Sialyllactose sodium (0-250 μ; 24-36 h) increases extracellular sulphated proteoglycan accumulation, Col2a1 synthesis, and inhibits the effects of inflammatory cytokines[1].
In chondrocytes, 3'-Sialyllactose sodium (0-250 μM; 24 h) activates Sox9 expression while suppressing NF-κB activation[1]. In all strains, regardless of whether metabolic activation is present or absent, 3'-Sialyllactose sodium (0-5000 μg/plate) exhibits no mutagenic effect and exhibits no discernible growth inhibition or deposition[3]. In the presence or absence of metabolic activation, 3'-Sialyllactose sodium (1250 μg/mL) does not cause chromosomal aberrations and exhibits non-clastogenic effects[3]. |
|---|---|
| ln Vivo |
3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice from osteoarthritis-induced cartilage destruction[1].
Inducing micronuclei in mouse bone marrow cells with 3'-sialyllactose sodium (500, 1000, and 2000 mg/kg; oral administration; once) does not work[3]. The maximum tolerated dose (MTD) for male and female beagle dogs is greater than 2000 mg/kg, according to 3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals[3]. The highest dose tested for 3'-sialyllactose sodium (LD50) is above 20 g/kg bw[3]. |
| Animal Protocol |
8-week-old male C57BL/6 mice with medial meniscus surgery[1]
10, 50 and 100 mg/kg Oral gavage; 10-100 mg/kg three times a week; for 6 weeks |
| References |
|
| Molecular Formula |
C23H38NNAO19
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|---|---|
| Molecular Weight |
655.5329
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| Exact Mass |
655.193
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| CAS # |
128596-80-5
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| Related CAS # |
128596-80-5
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| PubChem CID |
71308479
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| Appearance |
Typically exists as solid at room temperature
|
| Hydrogen Bond Donor Count |
12
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| Hydrogen Bond Acceptor Count |
19
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
44
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| Complexity |
934
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| Defined Atom Stereocenter Count |
15
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| SMILES |
[Na+].O1[C@@]([H])([C@@]([H])([C@@]([H])(C([H])([H])O[H])O[H])O[H])[C@@]([H])([C@]([H])(C([H])([H])[C@@]1(C(=O)[O-])O[C@]1([H])[C@]([H])([C@]([H])(O[C@]([H])([C@@]([H])(C([H])([H])O[H])O[H])[C@@]([H])([C@]([H])(C([H])=O)O[H])O[H])O[C@]([H])(C([H])([H])O[H])[C@]1([H])O[H])O[H])O[H])N([H])C(C([H])([H])[H])=O
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| InChi Key |
LTWFUJWFLMHANB-YZMHZYKKSA-M
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| InChi Code |
InChI=1S/C23H39NO19.Na/c1-7(29)24-13-8(30)2-23(22(38)39,42-19(13)15(35)10(32)4-26)43-20-16(36)12(6-28)40-21(17(20)37)41-18(11(33)5-27)14(34)9(31)3-25;/h3,8-21,26-28,30-37H,2,4-6H2,1H3,(H,24,29)(H,38,39);/q;+1/p-1/t8-,9-,10+,11+,12+,13?,14+,15+,16-,17+,18+,19+,20-,21-,23-;/m0./s1
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| Chemical Name |
sodium;(2S,4S,6R)-5-acetamido-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
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| Synonyms |
3'-Sialyllactose sodium; 3'-SL sodium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~381.37 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5255 mL | 7.6274 mL | 15.2548 mL | |
| 5 mM | 0.3051 mL | 1.5255 mL | 3.0510 mL | |
| 10 mM | 0.1525 mL | 0.7627 mL | 1.5255 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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