Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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4'-O-Methylresveratrol is a novel and potent resveratrol analogue derived from Dipterocarpaceae. Numerous biological effects of 4'-O-Methylresveratrol include antiandrogenic, antifungal, and anti-inflammatory properties. 4'-Methoxyresveratrol may reduce AGE-induced inflammation by inhibiting the RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
Molecular Formula |
C15H14O3
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Molecular Weight |
242.26986
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Exact Mass |
242.09
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Elemental Analysis |
C, 74.36; H, 5.82; O, 19.81
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CAS # |
33626-08-3
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Related CAS # |
33626-08-3
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Appearance |
Solid powder
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SMILES |
COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)O
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InChi Key |
IHVRWFJGOIWMGC-NSCUHMNNSA-N
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InChi Code |
InChI=1S/C15H14O3/c1-18-15-6-4-11(5-7-15)2-3-12-8-13(16)10-14(17)9-12/h2-10,16-17H,1H3/b3-2+
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Chemical Name |
5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol
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Synonyms |
4'-O-Methylresveratrol
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HS Tariff Code |
2934.99.03.00
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 48~50 mg/mL (198.1~206.4 mM)
Ethanol: ~48 mg/mL (~198.1 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.32 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.32 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.1276 mL | 20.6381 mL | 41.2763 mL | |
5 mM | 0.8255 mL | 4.1276 mL | 8.2553 mL | |
10 mM | 0.4128 mL | 2.0638 mL | 4.1276 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
4′-Methoxyresveratrol modulated pro-inflammatory gene expression induced by MB in RAW264.7 macrophages. Molecules . 2018 Jun 14;23(6):1447. td> |
4′-Methoxyresveratrol alleviated oxidative stress induced by MB in RAW264.7 macrophages. Molecules . 2018 Jun 14;23(6):1447. td> |
4′-Methoxyresveratrol inhibited RAGE expression induced by MB in RAW264.7 macrophages: (A) RAGE mRNA level was determined by qPCR. Molecules . 2018 Jun 14;23(6):1447. td> |
4′-Methoxyresveratrol down-regulated MAPKs/NF-κB signaling pathway activation induced by MB in RAW264.7 macrophages. Molecules . 2018 Jun 14;23(6):1447. td> |
4′-Methoxyresveratrol counteracted NLRP3 inflammasome activation induced by MB in RAW264.7 macrophages. Molecules . 2018 Jun 14;23(6):1447. td> |