| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
SIRT3
|
|---|---|
| ln Vitro |
5-Heptadecylresorcinol boosts SIRT3 in HUVECs [1] to reduce mitochondrial dysfunction at 0, 0.5, 1, and 2 µM during a 24-hour period. 5-Heptadecylresorcinol reduces mitochondrial damage and adipocyte lipolysis brought on by inflammatory conditioned medium (CM), while also reducing the generation of reactive oxygen species inside the mitochondria and the depolarization of the mitochondrial membrane [2]. By decreasing the release of glycerol from 3T3-L1 adipocytes, 5-Heptadecylresorcinol (5, 10 and 15 μM; 24 hours) significantly inhibits CM-induced lipolysis in adipocytes [2]. 5-Adipocytes with CM-induced mitochondrial dysfunction are improved by 5-Heptadecylresorcinol (5, 10 and 15 μM; 24 hours) [2].
|
| ln Vivo |
5-Heptadecylresorcinol (30 mg/kg, 150 mg/kg; taken orally daily for 16 weeks) enhances lipid metabolism in mice fed a high-fat diet that are ApoE−/− [1]. 5-Heptadecylresorcinol improves body weight and decreases mitochondrial dysfunction and adipose tissue macrophage infiltration in mice when given orally every day for 16 weeks (30 mg/kg, 150 mg/kg) [2].
|
| Cell Assay |
Western Blot Analysis[2]
Cell Types: 3T3-L1 adipocytes Tested Concentrations: 5, 10 and 15 μM Incubation Duration: 24 hrs (hours) Experimental Results: Increased the expression of UCP1, COX IV, PGC-1α, DRP1 and MFN2 proteins. |
| Animal Protocol |
Animal/Disease Models: C57BL/6J mice[1][2]
Doses: 30 mg/kg, 150 mg/kg Route of Administration: PO; daily for 16 weeks Experimental Results: Lowered serum total cholesterol, triglyceride, VLDL-C, and LDL-C levels[1]. diminished adipose tissue macrophage infiltration from high-fat diet induced obese C57BL/6J mice[2]. |
| References |
|
| Additional Infomation |
5-heptadecylresorcinol is a 5-alkylresorcinol that is resorcinol which is substituted by a heptadecyl group at position 5. It is found in wheat bran. It has a role as an antineoplastic agent and a plant metabolite.
5-Heptadecylbenzene-1,3-diol has been reported in Hordeum vulgare, Secale cereale, and other organisms with data available. |
| Molecular Formula |
C23H40O2
|
|---|---|
| Exact Mass |
348.302
|
| CAS # |
41442-57-3
|
| PubChem CID |
181700
|
| Appearance |
Off-white to light yellow solid powder
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
478.0±15.0 °C at 760 mmHg
|
| Melting Point |
91 - 93 °C
|
| Flash Point |
202.6±15.0 °C
|
| Vapour Pressure |
0.0±1.2 mmHg at 25°C
|
| Index of Refraction |
1.507
|
| LogP |
9.72
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
16
|
| Heavy Atom Count |
25
|
| Complexity |
269
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BBGNINPPDHJETF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C23H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-18-22(24)20-23(25)19-21/h18-20,24-25H,2-17H2,1H3
|
| Chemical Name |
5-heptadecylbenzene-1,3-diol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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