| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vivo |
Pretreated with 7-chlorokynurenic acid (10 nM), male Sprague-Dawley rats exhibit a marked delay in the development of the motor (17.7 ± 2.9 stimulations per day) and electroencephalographic (17.7 ± 2.9 stimulations per day) components of the epileptic response [3].
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| References |
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| Additional Infomation |
7-chlorokynurenic acid is a quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid. It has a role as a neuroprotective agent and a NMDA receptor antagonist. It is an organochlorine compound and a quinolinemonocarboxylic acid.
7-Chlorokynurenic acid has been reported in Streptomyces with data available. |
| Molecular Formula |
C10H6CLNO3
|
|---|---|
| Molecular Weight |
223.61
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| Exact Mass |
223.004
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| CAS # |
18000-24-3
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| Related CAS # |
7-Chlorokynurenic acid sodium salt;1263094-00-3
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| PubChem CID |
1884
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| Appearance |
White to off-white solid powder
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| Density |
1.549 g/cm3
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| Boiling Point |
395ºC at 760 mmHg
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| Flash Point |
192.7ºC
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| Vapour Pressure |
6E-07mmHg at 25°C
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| Index of Refraction |
1.648
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| LogP |
2.292
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
15
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| Complexity |
340
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
UAWVRVFHMOSAPU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
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| Chemical Name |
7-Chloro-4-hydroxyquinoline-2-carboxylic acid
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| Synonyms |
7CKA 7 CKA7-CKA 7-CTKA 7 CTKA7CTKA NSC 149792 NSC-149792NSC149792 7-Chlorokynurenic Acid 7 Chlorokynurenic Acid7-chloro KYNA 7 chloro KYNA
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~16.67 mg/mL (~74.55 mM)
H2O : ~1 mg/mL (~4.47 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (7.47 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4721 mL | 22.3604 mL | 44.7207 mL | |
| 5 mM | 0.8944 mL | 4.4721 mL | 8.9441 mL | |
| 10 mM | 0.4472 mL | 2.2360 mL | 4.4721 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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