Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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Targets |
NiRAN[1]
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ln Vitro |
Normal human bronchial and nasal epithelial cells treated with 10 μM AT-511 (698 μM and 236 μM, respectively) produce significant levels of the active triphosphate metabolite AT-9010, which has a half-life of at least 38 hours [1].
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References |
[1]. Atea Pharmaceuticals Announces Publication of Preclinical Data Highlighting Potent Activity of AT-527 Against SARS-CoV-2. BOSTON, Feb. 08, 2021. Atea Pharmaceuticals, Inc.
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Molecular Formula |
C11H13FN5NA4O13P3
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Molecular Weight |
627.13
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CAS # |
1621884-18-1
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Related CAS # |
AT-9010;1261253-79-5;AT-9010 triethylamine;2648089-95-4
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
C[C@]1([C@@H]([C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]1N1C=NC2C(N=C(N)NC1=2)=O)O)F.[Na+].[Na+].[Na+].[Na+]
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : 100 mg/mL (159.46 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (159.46 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.5946 mL | 7.9728 mL | 15.9457 mL | |
5 mM | 0.3189 mL | 1.5946 mL | 3.1891 mL | |
10 mM | 0.1595 mL | 0.7973 mL | 1.5946 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.