| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| Targets |
IC50: 81 nM (DNA-PK)[1]
|
|---|---|
| ln Vivo |
BAY-8400 boosts antitumor efficaciousness at 150 mg/kg or po. Oral bioavailability and cross-species water solubility are demonstrated by BAY-8400 [1].
|
| References |
| Molecular Formula |
C21H17F2N5O
|
|---|---|
| Molecular Weight |
393.39
|
| Exact Mass |
393.14
|
| Elemental Analysis |
C, 64.12; H, 4.36; F, 9.66; N, 17.80; O, 4.07
|
| CAS # |
2763602-59-9
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| PubChem CID |
162366965
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.45±0.1 g/cm3(Predicted)
|
| LogP |
3.2
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
29
|
| Complexity |
606
|
| Defined Atom Stereocenter Count |
0
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| SMILES |
FC([H])(C1=C([H])N=C([H])C(=C1[H])C1C([H])=C([H])C2=C(C=1[H])N1C(C([H])=N2)=NN=C1C1=C([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])F
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| InChi Key |
ATKHYZXUMVNCIO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H17F2N5O/c22-20(23)16-8-15(10-24-11-16)14-3-4-17-18(9-14)28-19(12-25-17)26-27-21(28)13-2-1-6-29-7-5-13/h2-4,8-12,20H,1,5-7H2
|
| Chemical Name |
8-[5-(difluoromethyl)pyridin-3-yl]-1-(2,3,6,7-tetrahydrooxepin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
|
| Synonyms |
BAY-8400; BAY8400; BAY 8400;
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : 62.5 mg/mL (158.88 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.29 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5420 mL | 12.7100 mL | 25.4201 mL | |
| 5 mM | 0.5084 mL | 2.5420 mL | 5.0840 mL | |
| 10 mM | 0.2542 mL | 1.2710 mL | 2.5420 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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