| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vivo |
CXCR2-IN-2 (Compound 68) (1-10 mg/kg; orally; twice daily for 3 days) dose-dependently inhibits in vivo neutrophil infiltration in rat and mouse air sac models [1] .
|
|---|---|
| Animal Protocol |
Animal/Disease Models: 6-8 weeks old male C57Bl/6 mice (mouse air sac model) [1]
Doses: 1, 3 and 10 mg/kg Route of Administration: Oral; twice (two times) daily for 3 days Experimental Results: Significant Inhibition of neutrophil infiltration into mouse air sacs. Animal/Disease Models: 8-10 week old male Wistar rat (rat air sac model) [1] Doses: 1, 3 and 10 mg/kg Route of Administration: po (po (oral gavage)) twice (two times) daily for 3 days Experimental Results: Inhibition of neutrophils Cell migration toward rat air sacs. |
| References |
| Molecular Formula |
C18H23CLN2O5S
|
|---|---|
| Molecular Weight |
414.903622865677
|
| Exact Mass |
414.101
|
| CAS # |
1838123-21-9
|
| Related CAS # |
(R,R)-CXCR2-IN-2;1838123-22-0
|
| Appearance |
White to off-white solid powder
|
| LogP |
2.2
|
| SMILES |
ClC1=CC=C(C(=C1S([C@]1(C)COCC1)(=O)=O)O)NC(N[C@H]1C(C)=CCC1)=O
|
| InChi Key |
DNXKACKCTLURQN-ACJLOTCBSA-N
|
| InChi Code |
InChI=1S/C18H23ClN2O5S/c1-11-4-3-5-13(11)20-17(23)21-14-7-6-12(19)16(15(14)22)27(24,25)18(2)8-9-26-10-18/h4,6-7,13,22H,3,5,8-10H2,1-2H3,(H2,20,21,23)/t13-,18+/m1/s1
|
| Chemical Name |
1-[4-chloro-2-hydroxy-3-[(3S)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]urea
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~240 mg/mL (~578.45 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6 mg/mL (14.46 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 60.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4102 mL | 12.0511 mL | 24.1022 mL | |
| 5 mM | 0.4820 mL | 2.4102 mL | 4.8204 mL | |
| 10 mM | 0.2410 mL | 1.2051 mL | 2.4102 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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