Size | Price | |
---|---|---|
100mg | ||
250mg | ||
500mg | ||
Other Sizes |
References |
1: Havlíková M, Jugl A, Krouská J, Szabová J, Mravcová L, Venerová T, Chang CH, Pekař M, Mravec F. Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan-A Physicochemical Study. Langmuir. 2021 Jul 20;37(28):8525-8533. doi: 10.1021/acs.langmuir.1c00993. Epub 2021 Jul 2. PMID: 34214390. 2: Gonçalves RA, Lam YM, Lindman B. Double-Chain Cationic Surfactants: Swelling, Structure, Phase Transitions and Additive Effects. Molecules. 2021 Jun 28;26(13):3946. doi: 10.3390/molecules26133946. PMID: 34203337; PMCID: PMC8271693. 3: Rusli W, van Herk AM. Effect of salts on size and morphology of extruded dimethyldioctadecylammonium bromide or chloride vesicle for polymeric nanocapsules synthesis via templating emulsion polymerization. J Colloid Interface Sci. 2021 Apr;587:393-401. doi: 10.1016/j.jcis.2020.11.116. Epub 2020 Dec 25. PMID: 33370661. 4: Hishida M, Shimokawa N, Okubo Y, Taguchi S, Yamamura Y, Saito K. Phase Transition from the Interdigitated to Bilayer Membrane of a Cationic Surfactant Induced by Addition of Hydrophobic Molecules. Langmuir. 2020 Dec 8;36(48):14699-14709. doi: 10.1021/acs.langmuir.0c02609. Epub 2020 Nov 24. PMID: 33232164. 5: Khattab MH, Weaver M, Cook C, Kinder N, Vassar M. Public Speaker Characteristics at Meetings of the Dermatologic and Ophthalmic Drug Advisory Committee and the Ophthalmic Devices Panel. Am J Ophthalmol. 2021 Mar;223:28-32. doi: 10.1016/j.ajo.2020.09.043. Epub 2020 Nov 6. PMID: 33166500. 6: Luna ACL, Saraiva GKV, Chierice GO, Hesse H, Maria DA. Antiproliferative and proapoptotic effects of DODAC/synthetic phosphoethanolamine on hepatocellular carcinoma cells. BMC Pharmacol Toxicol. 2018 Jul 11;19(1):44. doi: 10.1186/s40360-018-0225-2. PMID: 29996919; PMCID: PMC6042440. 7: Oliveira ACN, Fernandes J, Gonçalves A, Gomes AC, Oliveira MECDR. Lipid-based Nanocarriers for siRNA Delivery: Challenges, Strategies and the Lessons Learned from the DODAX: MO Liposomal System. Curr Drug Targets. 2019;20(1):29-50. doi: 10.2174/1389450119666180703145410. PMID: 29968536. 8: Gonçalves RA, Lindman B, Miguel MG, Iwata T, Lam YM. Elucidating the effect of additives on the alkyl chain packing of a double tail cationic surfactant. J Colloid Interface Sci. 2018 Oct 15;528:400-409. doi: 10.1016/j.jcis.2018.05.092. Epub 2018 May 26. PMID: 29879617. 9: Luna ACL, Santos Filho JRA, Hesse H, Neto SC, Chierice GO, Maria DA. Modulation of pro-apoptotic effects and mitochondrial potential on B16F10 cells by DODAC/PHO-S liposomes. BMC Res Notes. 2018 Feb 14;11(1):126. doi: 10.1186/s13104-018-3170-7. PMID: 29444697; PMCID: PMC5813323. 10: Wang G, Miao Y, Sun Z, Zheng S. Simultaneous adsorption of aflatoxin B1 and zearalenone by mono- and di-alkyl cationic surfactants modified montmorillonites. J Colloid Interface Sci. 2018 Feb 1;511:67-76. doi: 10.1016/j.jcis.2017.09.074. Epub 2017 Sep 25. PMID: 28972897. 11: Rezaee M, Oskuee RK, Nassirli H, Malaekeh-Nikouei B. Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems. J Control Release. 2016 Aug 28;236:1-14. doi: 10.1016/j.jconrel.2016.06.023. Epub 2016 Jun 15. PMID: 27317365. 12: Oliveira ACN, Sárria MP, Moreira P, Fernandes J, Castro L, Lopes I, Côrte- Real M, Cavaco-Paulo A, Real Oliveira MECD, Gomes AC. Counter ions and constituents combination affect DODAX : MO nanocarriers toxicity in vitro and in vivo. Toxicol Res (Camb). 2016 Jun 13;5(4):1244-1255. doi: 10.1039/c6tx00074f. PMID: 30090429; PMCID: PMC6062248. 13: Luna AC, Saraiva GK, Filho OM, Chierice GO, Neto SC, Cuccovia IM, Maria DA. Potential antitumor activity of novel DODAC/PHO-S liposomes. Int J Nanomedicine. 2016 Apr 18;11:1577-91. doi: 10.2147/IJN.S90850. PMID: 27143880; PMCID: PMC4841408. 14: Lopes I, C N Oliveira A, P Sárria M, P Neves Silva J, Gonçalves O, Gomes AC, Real Oliveira ME. Monoolein-based nanocarriers for enhanced folate receptor- mediated RNA delivery to cancer cells. J Liposome Res. 2016 Sep;26(3):199-210. doi: 10.3109/08982104.2015.1076463. Epub 2015 Aug 17. PMID: 26340109. 15: Shin MJ, Kim YJ, Kim JD. Chromatic response of polydiacetylene vesicle induced by the permeation of methotrexate. Soft Matter. 2015 Jul 7;11(25):5037-43. doi: 10.1039/c5sm00925a. Erratum in: Soft Matter. 2015 Sep 14;11(34):6903-4. PMID: 26016992. 16: Park CY, Kim MW. Dynamic mechanical properties of a polyelectrolyte adsorbed insoluble lipid monolayer at the air-water interface. J Phys Chem B. 2015 Apr 23;119(16):5315-20. doi: 10.1021/jp5123773. Epub 2015 Apr 14. PMID: 25826703. 17: Nakamura A, Endo H, Yamashita T, Kawai T. Sodium dodecylsulfate bilayer formation under a cationic surfactant Langmuir monolayer at the air-water interface. J Nanosci Nanotechnol. 2014 Mar;14(3):2198-203. doi: 10.1166/jnn.2014.8522. PMID: 24745212. 18: Oliveira AC, Martens TF, Raemdonck K, Adati RD, Feitosa E, Botelho C, Gomes AC, Braeckmans K, Real Oliveira ME. Dioctadecyldimethylammonium:monoolein nanocarriers for efficient in vitro gene silencing. ACS Appl Mater Interfaces. 2014 May 14;6(9):6977-89. doi: 10.1021/am500793y. Epub 2014 Apr 18. PMID: 24712543. 19: Sabatino P, Choudhury RP, Schönhoff M, Van der Meeren P, Martins JC. NMR investigation of exchange dynamics and binding of phenol and phenolate in DODAC vesicular dispersions. J Phys Chem B. 2012 Aug 2;116(30):9269-76. doi: 10.1021/jp304749g. Epub 2012 Jul 12. PMID: 22731738. 20: Woiterski L, Britt DW, Käs JA, Selle C. Oriented confined water induced by cationic lipids. Langmuir. 2012 Mar 13;28(10):4712-22. doi: 10.1021/la205043x. Epub 2012 Mar 1. PMID: 22339557.
|
---|
Molecular Formula |
C38H76CLN
|
---|---|
Molecular Weight |
582.483
|
Exact Mass |
581.57
|
Elemental Analysis |
C, 78.36; H, 13.15; Cl, 6.09; N, 2.40
|
CAS # |
7212-69-3
|
Related CAS # |
7212-69-3 (chloride);45315-43-3 (cation);
|
Appearance |
Light yellow to yellow viscouse liquid
|
SMILES |
CCCCCCCC/C=C\CCCCCCCC[N+](C)(C)CCCCCCCC/C=C\CCCCCCCC.[Cl-]
|
InChi Key |
UAKOZKUVZRMOFN-JDVCJPALSA-M
|
InChi Code |
InChI=1S/C38H76N.ClH/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(3,4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2;/h19-22H,5-18,23-38H2,1-4H3;1H/q+1;/p-1/b21-19-,22-20-;
|
Chemical Name |
(Z)-N,N-dimethyl-N-((Z)-octadec-9-en-1-yl)octadec-9-en-1-aminium chloride
|
Synonyms |
DODAC; Adogen 472; Arquad 20-75I; Cation 2OLR; Dimethyldioleylammonium chloride; Dioleyldimethylammonium chloride; Lipoquad 20-75I; N,N-Dioleyl-N,N-dimethylammonium chloride; Nissan Cation 2OLR; Soft and Dry
|
HS Tariff Code |
2934.99.9001
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
---|---|
Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80: Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 :Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.7168 mL | 8.5840 mL | 17.1680 mL | |
5 mM | 0.3434 mL | 1.7168 mL | 3.4336 mL | |
10 mM | 0.1717 mL | 0.8584 mL | 1.7168 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.