Size | Price | Stock | Qty |
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100mg |
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Other Sizes |
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Targets |
HIV[1]
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ln Vitro |
In a similar manner, dimercaprol (10-100 μM; 4 hours) can significantly protect PC-12 cells from formaldehyde-mediated cell death [2].
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ln Vivo |
Dimercaprol (2,3-Dimercapto-1-propanol; 12.5-75 mg/kg; subcutaneous injection; once) increases the agent and decreases mercury levels in the liver and water [3].
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Cell Assay |
Cell Viability Assay[2]
Cell Types: PC-12 cells Tested Concentrations: 10, 25, 50 and 100 μM Incubation Duration: 4 hrs (hours) Experimental Results: Significant protection of PC-12 cells from acrolein-mediated cell damage in a dose-dependent manner die. |
Animal Protocol |
Animal/Disease Models: Wistar rats (13 days old)) injected with HgCl2[3]
Doses: 12.5 mg/kg, 25 mg/kg, 50 mg/kg or 75 mg/kg Route of Administration: subcutaneous injection; primary Experimental Results:diminished liver function and mercury levels in the kidneys. |
References |
[1]. Kubota S, et al. 2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. AIDS Res Hum Retroviruses. 1990 Jul;6(7):919-27.
[2]. Ran Tian, et al. Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. J Neurochem. 2017 Jun;141(5):708-720. [3]. Taciane Roza, et al. 2,3-Dimercapto-1-propanol does not alter the porphobilinogen synthase inhibition but decreases the mercury content in liver and kidney of suckling rats exposed to HgCl2. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):302-8. |
Molecular Formula |
C3H8OS2
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Molecular Weight |
124.23
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CAS # |
59-52-9
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
C(C(CS)S)O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : 41.67 mg/mL (335.43 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (804.96 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 8.0496 mL | 40.2479 mL | 80.4959 mL | |
5 mM | 1.6099 mL | 8.0496 mL | 16.0992 mL | |
10 mM | 0.8050 mL | 4.0248 mL | 8.0496 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.