| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
|
| Targets |
CA Ⅸ 0.33 μM (IC50) CA XII 0.68 μM (IC50) NPP1 1.13 μM (IC50) NPP2 1.07 μM (IC50) NPP3 0.74 μM (IC50)
|
|---|---|
| ln Vitro |
Compound 1i (Enpp/Carbonic anhydrase-IN-2) (0-100 µM) inhibits the growth of some cancer cells with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, and T-47D cells, respectively[1]. Normal skin fibroblast cells (F180) and normal breast epithelial cells (HME1) exhibit minimal cytotoxicity when exposed to Enpp/Carbonic anhydrase-IN-2 (0-2 µM), with IC50s of > 50 μM[1]. A dose-dependent mechanism of apoptosis induction is shown in K-562 cells by Enpp/ Carbonic anhydrase-IN-2 (0.58, 1.16 µM)[1].
|
| Cell Assay |
Cell Proliferation Assay[1]
Cell Types: K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells Tested Concentrations: 0-100 µM Incubation Duration: Experimental Results: Inhibited the cell growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively. Apoptosis Analysis[1] Cell Types: K-562 cells Tested Concentrations: 0.58, 1.16 µM Incubation Duration: Experimental Results: Induced apoptosis in a dose-dependent manner. |
| References |
[1]. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.
|
| Molecular Formula |
C23H24FNO4S
|
|---|---|
| Molecular Weight |
429.50
|
| CAS # |
2883495-39-2
|
| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : 100 mg/mL (232.83 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.82 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3283 mL | 11.6414 mL | 23.2829 mL | |
| 5 mM | 0.4657 mL | 2.3283 mL | 4.6566 mL | |
| 10 mM | 0.2328 mL | 1.1641 mL | 2.3283 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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