Size | Price | Stock | Qty |
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100mg |
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Other Sizes |
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Targets |
COX-2 Human Endogenous Metabolite
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ln Vitro |
Gallic acid is an antioxidant that has the ability to block COX-2[1]. The number of viable neutrophils after an 18-hour treatment with gallic acid drops sharply from 40.3% to 27.7%, which is quite similar to the 26.4% of neutrophils that were not treated. The myocytolysis caused by isoproterenol cannot be inhibited by gallic acid[3].
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ln Vivo |
There is no significant difference seen between the food consumption (2.6±0.08 g/day, p=0.69) and body weight (2.5±0.69 g, p=0.76) of the Gallic acid group and the control group (food intake: 2.41± 0.14 g/day and body weight: 2.83±0.84 g/day). After two weeks of treatment, there is a considerable improvement in the blood glucose tolerance of the gallic acid group. Following a two-week treatment period, the blood glucose tolerance of the Gallic acid group is likewise considerably better at 90 and 120 minutes (p<0.05) than that of the control group. Compared to the control group (1.08±0.20 mM), the serum triglyceride concentration in the gallic acid group (0.67±0.03 mM, p<0.05) is much lower. The control group's total cholesterol concentration (3.19±0.27 mM) and the gallic acid group's (3.01±0.18 mM) concentrations are comparable[2].
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References |
[1]. Amaravani M, et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58.
[2]. Bak EJ, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14. [3]. Cheng Y, et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Oxid Med C [4]. Felipe Hugo Alencar Fernandes, et al. Gallic Acid: Review of the Methods of Determination and Quantification. Crit Rev Anal Chem |
Molecular Formula |
C7H8O6
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Molecular Weight |
188.13
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CAS # |
5995-86-8
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Related CAS # |
Gallic acid;149-91-7
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O([H])C1C(=C([H])C(C(=O)O[H])=C([H])C=1O[H])O[H].O([H])[H]
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 50 mg/mL (265.77 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.29 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.29 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (13.29 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.3155 mL | 26.5774 mL | 53.1547 mL | |
5 mM | 1.0631 mL | 5.3155 mL | 10.6309 mL | |
10 mM | 0.5315 mL | 2.6577 mL | 5.3155 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.