Size | Price | Stock | Qty |
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100mg |
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500mg |
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1g |
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5g |
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Other Sizes |
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ln Vitro |
At varying substrate doses (10-150 μM), NCGC00092410 (7.3-130 nM; 25 min) reduces GC activity in a dose-dependent manner [1]. N370S mutant cells exhibit increased GC activity in response to NCGC00092410 (55-40 μM; 2 d) [1]. In Gaucher fibroblasts, NCGC00092410 (40 μM; 60-72 hours) enhances the lysosomal localization of GCs [1].
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References |
[1]. Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7.
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Molecular Formula |
C21H27N3O2
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Molecular Weight |
353.466
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Exact Mass |
353.21
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Elemental Analysis |
C, 71.36; H, 7.70; N, 11.89; O, 9.05
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CAS # |
442898-34-2
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Appearance |
Solid powder
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SMILES |
O=C(C1CCCCC1)NC2=CC=C3N=C(N4CCOCC4)C=C(C)C3=C2
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InChi Key |
BXVNPOBNVRBOOV-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C21H27N3O2/c1-15-13-20(24-9-11-26-12-10-24)23-19-8-7-17(14-18(15)19)22-21(25)16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H,22,25)
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Chemical Name |
N-[4-Methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide
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Synonyms |
ML008; ML-008; ML 008; NCGC00092410; NCGC-00092410; NCGC 00092410;
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~41.67 mg/mL (~117.89 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.88 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8291 mL | 14.1455 mL | 28.2909 mL | |
5 mM | 0.5658 mL | 2.8291 mL | 5.6582 mL | |
10 mM | 0.2829 mL | 1.4145 mL | 2.8291 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.