| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| Other Sizes |
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| Targets |
Aminoglycoside
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|---|---|
| ln Vitro |
Micronomicin exhibits strong antibacterial properties; it effectively combats Staphylococcus aureus FDA 209 P, exhibiting minimal inhibitory values of 0.01 μg/ml. Additionally, it is anti-Escherichia coli St. M. The minimal inhibitory values were 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml, and 0.03 μg/ml for 589, Baker 2, F 14-BK, and R5/W677. Additionally, it exhibits activity against strains of Lebsiella pneumoniae and Pseudomonas aeruginosa (MICs = 0.03-17.5 μg/ml)[1].
|
| ln Vivo |
Micronomicin sulfate has an intravenous acute LD50 of 93 mg/kg in mice and is very effective against a variety of bacterial infections in mice[1]. Subacute toxicity studies involve the intravenous injection of micronomicin sulfate at a dose of 4-100 mg/kg over a 30-day period. Ataxia and renal problems cause the wistar rats (10 out of 30 animals) to die at the 100 mg/kg dose. Renal histopathological abnormalities primarily manifest at dosages beyond 25 mg/kg [3].
|
| Animal Protocol |
Animal/Disease Models: Wistar rats[3]
Doses: 4, 10, 25, 63 mg/kg and 100 mg/kg Route of Administration: intravenous (iv)injection; 30 days Experimental Results: Led to death of rat at 100 mg/kg. |
| References |
[1]. R Okachi,et al. A New Antibiotic XK-62-2 (Sagamicin). I. Isolation, Physicochemical and Antibacterial Properties. J Antibiot (Tokyo)
[2]. P J Daniels, The Gentamicin Antibiotics. 6. Gentamicin C2b, an Aminoglycoside Antibiotic Produced by Micromonospora Purpurea Mutant JI-33. J Antibiot (Tokyo) [3]. T Hara, et al. Safety Evaluation of Micronomicin V. Subacute Toxicity in Rats After Intravenous Injection. Jpn J Antibiot. 1983 Nov;36(11):3208-25. |
| Molecular Formula |
C20H41N5O7.XH2SO4
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|---|---|
| Molecular Weight |
561.64732
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| CAS # |
66803-19-8
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| Related CAS # |
Micronomicin;52093-21-7
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
OS(=O)(O)=O.CNC[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : 50 mg/mL
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7805 mL | 8.9023 mL | 17.8047 mL | |
| 5 mM | 0.3561 mL | 1.7805 mL | 3.5609 mL | |
| 10 mM | 0.1780 mL | 0.8902 mL | 1.7805 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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