Size | Price | Stock | Qty |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
Quipazine dimaleate exhibits 230 nM Ki values and binding potency for both 5-HT1 and 5-HT2 [3]. With a Ki value of 1.4 nM, quipazine dimaleate replaces [3H]GR65630 at 5-HT3R in rat endothelium [3]. The rat vagus nerve is antagonistically affected by quipazine dimaleate; its pIC50 values for 5-HT2, 5-HT1, and inhibition of 5-HT release are, respectively, 6.1, 6.49, and 6.17 [4].
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ln Vivo |
In male and female rats, quipazine dimaleate (2.5, 5, and 7.5 mg/kg, once each; i.p.) influences the nutritional self-selection of various macronutrient diets [1].
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Animal Protocol |
Animal/Disease Models: Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein , corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)[1]
Doses: 2.5, 5 and 7.5 mg/kg Route of Administration: intraperitoneal (ip)injection; 2.5, 5 and 7.5 mg/kg, one dose for once Experimental Results: Increased water intake and food intake of male rats from Group S, and diminished food intake of female rats from Group 1 and Group 2s at 2h post-injection. diminished food intake in female rats from Group 2, diminished protein intake in female rats from Group 1. |
References |
[1]. Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25.
[2]. Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646. [3]. Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. [4]. Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90(1):229-38. |
Molecular Formula |
C21H23N3O8
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Molecular Weight |
445.42
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Elemental Analysis |
C, 56.63; H, 5.20; N, 9.43; O, 28.73
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CAS # |
150323-78-7
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Related CAS # |
Quipazine;4774-24-7
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Appearance |
Solid powder
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SMILES |
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1CN(CCN1)C1=NC2=C(C=CC=C2)C=C1
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InChi Key |
VAOSOCRJSSWBEQ-SPIKMXEPSA-N
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InChi Code |
InChI=1S/C13H15N3.2C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;2*5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
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Chemical Name |
2-(1-Piperazinyl)quinoline dimaleate
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Synonyms |
Quipazine dimaleate
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 250 mg/mL (561.27 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.67 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2451 mL | 11.2254 mL | 22.4507 mL | |
5 mM | 0.4490 mL | 2.2451 mL | 4.4901 mL | |
10 mM | 0.2245 mL | 1.1225 mL | 2.2451 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.