Size | Price | Stock | Qty |
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500mg |
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Other Sizes |
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Targets |
Bacterial[1]
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ln Vivo |
Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) therapy considerably increases t1/2α, Vd, and CIB and significantly reduces α, β, and AUC0->∞. The absolute bioavailability of Sulfamethazine in pigs is 1.01 after a single intramuscular dosage of 80 mg/kg[1].
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Animal Protocol |
Animal/Disease Models: 19 healthy female pigs (6weeks old, 4.5-6.2 kg)[1]
Doses: 80 mg/kg Route of Administration: intravenous (iv)injection (pharmacokinetic/PK study) Experimental Results: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were Dramatically diminished and t1 /2α, Vd and CIB were Dramatically increased, and the absolute bioavailability in pigs is 1.01. |
References |
[1]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994 Sep;57(9):796-801.
[2]. Sheng Y J, et al. Production of chicken yolk IgY to sulfamethazine: comparison with rabbit antiserum IgG. Food and Agricultural Immunology. 2015, 26(3):305-316. |
Molecular Formula |
C12H13N4NAO2S
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Molecular Weight |
300.31
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CAS # |
1981-58-4
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Related CAS # |
Sulfamethazine;57-68-1;Sulfamethazine-d4;1020719-82-7
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
S(C1C([H])=C([H])C(=C([H])C=1[H])N([H])[H])([N-]C1=NC(C([H])([H])[H])=C([H])C(C([H])([H])[H])=N1)(=O)=O.[Na+]
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 250 mg/mL (832.47 mM)
H2O : 100 mg/mL (332.99 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.3299 mL | 16.6495 mL | 33.2989 mL | |
5 mM | 0.6660 mL | 3.3299 mL | 6.6598 mL | |
10 mM | 0.3330 mL | 1.6649 mL | 3.3299 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.