Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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Targets |
CDK1 Caspase-9 MCL1
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ln Vitro |
In KMS34 cells, TC11 (0~30 μM; 24 hours) causes cell death[1]. TC11 (5 μM; 0~48 hours; KMS34 cells) causes M arrest and downregulates MCL1 expression as well as an apoptotic pathway that leads to cell death[1].
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Cell Assay |
Cell Viability Assay[1]
Cell Types: KMS34 cells Tested Concentrations: 0~30 μM Incubation Duration: 24 hrs (hours) Experimental Results: Induced cell death. Western Blot Analysis[1] Cell Types: KMS34 cells Tested Concentrations: 5 μM Incubation Duration: 0~48 hrs (hours) Experimental Results: Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression. Cell Cycle Analysis[1] Cell Types: KMS34 cells Tested Concentrations: 5 μM Incubation Duration: 24 hrs (hours) Experimental Results: Induced M arrest. |
References |
[1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258.
[2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878. |
Molecular Formula |
C20H22N2O2
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Molecular Weight |
322.40
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CAS # |
100823-03-8
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
NC1=CC=C2C(C(=O)N(C3C(C(C)C)=CC=CC=3C(C)C)C2=O)=C1
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 50 mg/mL (155.09 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.1017 mL | 15.5087 mL | 31.0174 mL | |
5 mM | 0.6203 mL | 3.1017 mL | 6.2035 mL | |
10 mM | 0.3102 mL | 1.5509 mL | 3.1017 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.