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| 5mg |
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| 25mg |
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| 100mg |
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Purity: ≥98%
Abscisic Acid (also known as ABA, and Abscisin II) is a plant hormone and growth inhibitor, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth. ABA is a plant hormone and plays an important role in abiotic stress tolerance. Histone H2B monoubiquitination regulated ABA levels in developing seeds. H2B ubiquitination and ABA dependent chromatin remodeling regulated seed dormancy. Abiotic stress-induced ABA regulated stressresponsive gene expression and stomatal response.
| ln Vitro |
Abscisic acid ((S)-(+)-Abscisic acid; 10 μM) rapidly depolarizes the plasma membrane and alkalinizes the media in Arabidopsis cell cultures [1]. In suspensions of Arabidopsis cells, cytoplasmic Ca2+ is elevated by 10 μM abscisic acid. Abscisic acid increases cytosolic Ca2+ levels, which reduces proton pumping indirectly rather than directly [1]. Abscisic acid's natural receptor is called lanthionine synthase C-like 2 (LANCL2). Abscisic acid stimulates the metabolism of glucose and fatty acids in mitochondria, boosts the production of glycogen, activates PI3K independently of insulin, and facilitates the translocation of GLUT4 to the cell membrane at the biological level and in particular muscle cells ex vivo [2].
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| ln Vivo |
Glycemic control is improved by oral abscisic acid (0.125 μg/kg/day) over a duration of 12 weeks [2]. In the DIO model, abscisic acid (oral; 0.125 μg/kg/day; for 12 weeks) significantly decreased the levels of TNF, MCP-1, and IL-6. Skeletal muscle can have its metabolic activity increased by abscisic acid [2].
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| Animal Protocol |
Animal/Disease Models: Diet-induced obesity (DIO) mice at 4 weeks of age[2]
Doses: 0.125 µg/kg Route of Administration: po (oral gavage) daily; for 12 weeks Experimental Results: Improved glycemic control in a diet-induced model of obesity |
| References |
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| Additional Infomation |
(+)-abscisic acid is the naturally occurring (1'S)-(+) enantiomer of abscisic acid. It is an important sesquiterpenoid plant hormone which acts as a regulator of plant responses to environmental stresses such as drought and cold. It has a role as a plant hormone and a plant metabolite. It is a conjugate acid of a (+)-abscisate. It is an enantiomer of a (-)-abscisic acid.
Abscisic acid has been reported in Camellia sinensis, Pinus densiflora, and other organisms with data available. Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits. |
| Molecular Formula |
C15H20O4
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|---|---|---|
| Molecular Weight |
264.32
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| Exact Mass |
264.136
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| CAS # |
21293-29-8
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| Related CAS # |
Abscisic acid-d6;721948-65-8;(±)-Abscisic acid;14375-45-2;(±)-trans-Abscisic acid;2228-72-0
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| PubChem CID |
5280896
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
458.7±45.0 °C at 760 mmHg
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| Melting Point |
188ºC
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| Flash Point |
245.4±25.2 °C
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| Vapour Pressure |
0.0±2.5 mmHg at 25°C
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| Index of Refraction |
1.583
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| LogP |
1.7
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
19
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| Complexity |
494
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC1=CC(=O)CC([C@]1(/C=C/C(=C\C(=O)O)/C)O)(C)C
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| InChi Key |
JLIDBLDQVAYHNE-YKALOCIXSA-N
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| InChi Code |
InChI=1S/C15H20O4/c1-10(7-13(17)18)5-6-15(19)11(2)8-12(16)9-14(15,3)4/h5-8,19H,9H2,1-4H3,(H,17,18)/b6-5+,10-7-/t15-/m1/s1
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| Chemical Name |
(2Z,4E)-5-((S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-enyl)-3-methylpenta-2,4-dienoic acid
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (23.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 6.25 mg/mL (23.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 6.25 mg/mL (23.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7833 mL | 18.9165 mL | 37.8329 mL | |
| 5 mM | 0.7567 mL | 3.7833 mL | 7.5666 mL | |
| 10 mM | 0.3783 mL | 1.8916 mL | 3.7833 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT04722354 | Recruiting | Dietary Supplement: Oral abscisic acid (ABA) |
Pre Diabetes | AdventHealth Translational Research Institute |
March 8, 2021 | Phase 2 |
Products are for research use only; We do not sell to patients
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