Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
AC-262536 (AC262536) is a novel selective androgen receptor modulator (SARM) that has positive effects on growth. It suppresses luteinizing hormone and exhibits partial agonist activity toward testosterone. Its anabolic effects are beneficial and its androgenic effects are mild. AC-262536 is a new class of anabolic steroids that are selective androgen receptor modulators (SARMs).
ln Vitro |
AC-262536 dose-dependently prevents the proliferation of LNCaP that is induced by dihydroxytestosterone (DHT). The effects peak at 1 μM treatment (%inhibition 50.7±7.6) and are statistically significant at 100 nM AC-262536 (%inhibition 47.2±12.2). In prostate cells, AC-262536 can therefore function as a functional antagonist[1].
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ln Vivo |
In castrated rats, AC-262536 (3, 10, 30 mg/kg) reverses the luteinizing hormone (LH) spike[1].
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Animal Protocol |
Male Sprague-Dawley rats (200-225 g)[1]
3, 10 and 30 mg/kg Administered subcutaneously; once daily for 14 consecutive days |
References |
Molecular Formula |
C18H18N2O
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Molecular Weight |
278.36
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Exact Mass |
278.1419
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Elemental Analysis |
C, 77.67; H, 6.52; N, 10.06; O, 5.75
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CAS # |
870888-46-3
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Related CAS # |
870888-46-3
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Appearance |
Solid powder
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SMILES |
C1C[C@H]2CC(C[C@@H]1N2C3=CC=C(C4=CC=CC=C43)C#N)O
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InChi Key |
ATKWLNSCJYLXPF-YIONKMFJSA-N
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InChi Code |
InChI=1S/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15?
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Chemical Name |
4-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile
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Synonyms |
AC-262536; AC262536; AC 262536
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~50 mg/mL (~179.6 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.98 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: ≥ 0.56 mg/mL (2.01 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5925 mL | 17.9624 mL | 35.9247 mL | |
5 mM | 0.7185 mL | 3.5925 mL | 7.1849 mL | |
10 mM | 0.3592 mL | 1.7962 mL | 3.5925 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.