Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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Other Sizes |
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Molecular Formula |
C19H15NO6
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Molecular Weight |
353.33
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Exact Mass |
353.08994
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CAS # |
152-72-7
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Related CAS # |
Acenocoumarol-d5;1185071-64-0;Acenocoumarol-d4
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
CC(=O)CC(C1=CC=C(C=C1)[N+]([O-])=O)C1=C(O)C2=CC=CC=C2OC1=O
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InChi Key |
VABCILAOYCMVPS-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3
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Chemical Name |
4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]chromen-2-one
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Synonyms |
SintromG-23350SinthromeAcenocoumarinNicoumalone
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~283.02 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.08 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.08 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.89 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8302 mL | 14.1511 mL | 28.3022 mL | |
5 mM | 0.5660 mL | 2.8302 mL | 5.6604 mL | |
10 mM | 0.2830 mL | 1.4151 mL | 2.8302 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT03015025 | Completed | Genetic: Acenocoumarol | Atrial Fibrillation Venous Thromboses |
Instituto de Investigación Hospital Universitario La Paz |
October 2011 | |
NCT01851824 | Completed | Drug: acenocoumarol Drug: vemurafenib |
Malignant Melanoma, Neoplasms | Hoffmann-La Roche | August 2013 | Phase 1 |
NCT01631877 | Withdrawn | Drug: Enoxaparin with acenocoumarol Other: placebo |
Portal Vein Thrombosis | Institute of Liver and Biliary Sciences, India |
June 2012 | Not Applicable |
NCT05515120 | Completed | Drug: Aspirin 300mg Drug: Acenocoumarol Oral Tablet |
Venous Thromboembolism Anticoagulant-induced Bleeding |
Instituto Mexicano del Seguro Social | January 3, 2021 | Phase 2 Phase 3 |