| Size | Price | Stock | Qty |
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| 5g |
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| 10g |
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| 25g |
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| 100g |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
In studies pertaining to life sciences, acetylcholine (bromide) is a biochemical reagent that can be utilized as an organic substance or biological material.
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| References |
: Jayarangaiah A, Theetha Kariyanna P. Lambert Eaton Myasthenic Syndrome. 2018 Jun 20. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. PMID: 29939668.
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| Additional Infomation |
Acetylcholine bromide is the bromide salt of acetylcholine. It is a quaternary ammonium salt and a bromide salt. It contains an acetylcholine.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. |
| Molecular Formula |
C7H16BRNO2MOLECULARWEIGHT
|
|---|---|
| Molecular Weight |
226.1114
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| Exact Mass |
225.036
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| CAS # |
66-23-9
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| Related CAS # |
Acetylcholine chloride;60-31-1;Acetylcholine-d4 bromide;93449-31-1;Acetylcholine-d13 bromide;Acetylcholine-d16 bromide;347841-43-4;Acetylcholine-d9 bromide;93449-32-2
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| PubChem CID |
65551
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| Appearance |
White to light yellow solid powder
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| Melting Point |
140-143 °C(lit.)
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
11
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| Complexity |
115
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[Br-].O(C(C([H])([H])[H])=O)C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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| InChi Key |
ZEHGKSPCAMLJDC-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C7H16NO2.BrH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
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| Chemical Name |
2-acetyloxyethyl(trimethyl)azanium;bromide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~1105.66 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4226 mL | 22.1131 mL | 44.2263 mL | |
| 5 mM | 0.8845 mL | 4.4226 mL | 8.8453 mL | |
| 10 mM | 0.4423 mL | 2.2113 mL | 4.4226 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02357225 | TERMINATED | Drug: Pyridostigmine Bromide | Pompe Disease | University of Florida | 2015-08 | Early Phase 1 |
| NCT06487416 | ACTIVE, NOT RECRUITING | Drug: Tiotropium Bromide Inhalation Powder
Drug: Spiriva®Handihaler® |
Chronic Obstructive Pulmonary Disease (COPD) | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2024-06-10 | Phase 1 |
| NCT00782938 | COMPLETED | Acetylcholine BIS-EEG Cognition |
Heidelberg University | 2008-05 | ||
| NCT03554551 | COMPLETED | Parkinson Disease | Aarhus University Hospital | 2018-08-08 | ||
| NCT05618132 | RECRUITING | Diagnostic Test: Acetylcholine rechallenge | Angina Pectoris With Normal Coronary Arteriogram Angina Pectoris, Variant Angina Pectoris; Spasm-Induced |
University Hospital, Antwerp | 2023-01-09 | Not Applicable |
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