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Purity: ≥98%
Acetylcholine Chloride (ACh chloride; Ovisot; TL-1505; TL-1505) is an organic chemical and a common neurotransmitter found in the central and peripheral nerve system that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical released by nerve cells to send signals to other cells. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Substances that interfere with acetylcholine activity are called anticholinergics. is
| ln Vitro |
While sweat gland epithelial cell fluorescence values and intracellular free calcium are decreased in calcium-free myocardium, cardiac choline chloride (ACh chloride; 10 μM) calcium channel, fluorescence values, and intracellular free calcium are significantly increased in hypercalcium myocardium [3].
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| ln Vivo |
In mice, acetylcholine chloride (ACh chloride; SC; 20 mg/kg; single dose) significantly increases cholinergic stimulation and morbidity [4].
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| Animal Protocol |
Animal/Disease Models: Male and female inbred albino mice weighing 18-22 grams (sepsis) [4]
Doses: 20 mg/kg Route of Administration: subcutaneous injection; single dose Experimental Results: Dramatically diminished intraperitoneal (ip) injection of 2×109 large intestine Mortality of mice with sepsis caused by bacilli and blood levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6. |
| References |
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| Additional Infomation |
Acetylcholine chloride is the chloride salt of acetylcholine, and a parasympatomimetic drug. It contains an acetylcholine.
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mimics the parasympathomimetic effect of the endogenous compound acetylcholine. Administered as an ophthalmic solution, this drug stimulates the cholinoceptors in the sphincter muscle of the iris, causing the pupil to constrict. (NCI05) A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. See also: Acetylcholine (has active moiety); Chloride Ion (has part); Acetylcholine Chloride; Histamine; Serotonin (component of) ... View More ... |
| Molecular Formula |
C7H16NO2.CL
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| Molecular Weight |
181.66
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| Exact Mass |
181.086
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| CAS # |
60-31-1
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| Related CAS # |
Acetylcholine iodide;2260-50-6;Acetylcholine bromide;66-23-9;Acetylcholine-d4 chloride;344298-94-8;Acetylcholine-d9 chloride;344298-95-9
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| PubChem CID |
6060
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| Appearance |
White to off-white solid powder
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| Melting Point |
146-150 °C(lit.)
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
11
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| Complexity |
115
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
JUGOREOARAHOCO-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
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| Chemical Name |
2-acetyloxyethyl(trimethyl)azanium;chloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (11.45 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (11.45 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (11.45 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 23.33 mg/mL (128.43 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5048 mL | 27.5239 mL | 55.0479 mL | |
| 5 mM | 1.1010 mL | 5.5048 mL | 11.0096 mL | |
| 10 mM | 0.5505 mL | 2.7524 mL | 5.5048 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT06219590 | Recruiting | Procedure: Acetylcholine Iontophoresis Procedure: Shame Acetylcholine Iontophoresis |
Type 2 Diabetes Mellitus Peripheral Neuropathy |
South Valley University | October 28, 2023 | Not Applicable |
| NCT01137656 | Completed | Drug: Acetylcholine and Blood | Healthy | Mark Gladwin | April 2010 | Phase 1 |
| NCT03636100 | Terminated | Device: Cryoballoon ablation | Atrial Fibrillation | Saint Luke's Health System | August 15, 2018 | |
| NCT05618132 | Recruiting | Diagnostic Test: Acetylcholine rechallenge | Angina Pectoris, Variant Angina Pectoris; Spasm-Induced Angina Pectoris With Normal Coronary Arteriogram | University Hospital, Antwerp | January 9, 2023 | Not Applicable |
| NCT06180252 | Completed | Diagnostic Test: PET with 11C MP4 | Alzheimer Disease | IRCCS San Raffaele | May 12, 2004 |
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