| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 5g |
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| 10g |
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| 25g |
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Purity: ≥98%
Alizarin is a naturally occuring and anthraquinone-based dye extracted from the roots of madder plant. It has been widely used as a pigment in textile fabrics and paintings. Alizarin also exhibits antioxidant activity. It can be used for detecting the presence of calcium salts. Alizarin belongs to the anthraquinone group. It is a chelator for calcium and is commonly used to stain the calcifying or calcio-receptive zone of the collagenous matrix where calcium salts are being deposited. On the other hand, the Alizarin complexone is used for bone staining in vivo to study bone remodeling. Alizarin is proved to have anti-tumor efficacy. It suppresses the cell growth of the prostate cancer, breast cancer and osteosarcoma cell lines in vitro.
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| ln Vivo |
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| References |
Mutat Res.2002 Oct 31;508(1-2):147-56.
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| Additional Infomation |
Alizarin is a dihydroxyanthraquinone that is anthracene-9,10-dione in which the two hydroxy groups are located at positions 1 and 2. It has a role as a chromophore, a dye and a plant metabolite.
Alizarin has been reported in Rubia lanceolata, Rubia argyi, and other organisms with data available. See also: Rubia tinctorum root (part of). |
| Molecular Formula |
C14H8O4
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| Molecular Weight |
240.21
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| Exact Mass |
240.042
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| CAS # |
72-48-0
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| Related CAS # |
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| PubChem CID |
6293
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| Appearance |
Yellow to brown solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
430.0±40.0 °C at 760 mmHg
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| Melting Point |
287 °C
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| Flash Point |
228.0±23.8 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.733
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| LogP |
4.09
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
18
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| Complexity |
378
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
RGCKGOZRHPZPFP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H
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| Chemical Name |
1,2-dihydroxyanthracene-9,10-dione
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (10.41 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (10.41 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1630 mL | 20.8151 mL | 41.6302 mL | |
| 5 mM | 0.8326 mL | 4.1630 mL | 8.3260 mL | |
| 10 mM | 0.4163 mL | 2.0815 mL | 4.1630 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02329548 | Completed | Other: Alizarin Red | Postural Tachycardia Syndrome Syncope |
Nationwide Children's Hospital | December 2014 | Not Applicable |
| NCT03104166 | Completed | Device: Medium Cut-Off (MCO) dialysis membrane |
Vascular Calcification | Charite University, Berlin, Germany | January 22, 2018 | Not Applicable |
| NCT02676921 | Completed | Sinus; Empyema, Maxillary (Chronic) | BERBERI ANTOINE | March 2014 | ||
| NCT03105284 | Completed | Procedure: Liposuction | Mesenchymal Stem Cells | University of Aarhus | September 1, 2016 | Not Applicable |
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