Size | Price | Stock | Qty |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
α-Mangostin (α-Mangostin) suppresses IDH1-R132H but not IDH1. IDH1-R132H is inhibited by α-Mangostin (α-Mangostin). According to studies, the strongest core flipped structure is seen in α-Mangostin (α-Mangostin). α-Mangostin (α-Mangostin) preferentially stimulates the demethylation of trimethylated lysine residues in histone H3 and 5-methylcellulose (5mC) in IDH1 (+/R132H) MCF10A cells [1]. Cell proliferation was markedly and dose-dependently inhibited in cells treated with α-mangostin. Additionally, α-Mangosteen raises mitochondrial caspase-9, mitochondrial caspase-3, mitochondrial poly(ADP-ribose) polymerase (PARP), and pigmentogen Bax levels [2]. α-Mangostin (α-Mangostin) notably reduces fotoThe production of reactive oxygen species (ROS) and malondialdehyde (MDA) caused by light is inhibited by α-Mangostin (α-Mangostin) at 200 μM H2O2[3].
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ln Vivo |
By decreasing p53 expression in comparison to TAA_DMSO therapy, α-Mangostin (α-Mangostin) lowers the risk of liver fibrosis. Compared to DMSO alone, the therapy with α-Mangostin resulted in lower serum levels of the liver enzymes AST and ALT [4].
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References |
[1]. Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31.
[2]. Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48 |
Molecular Formula |
C24H26O6
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Molecular Weight |
410.4596
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Exact Mass |
410.17
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Elemental Analysis |
C, 70.23; H, 6.38; O, 23.39
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CAS # |
6147-11-1
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Related CAS # |
beta-Mangostin; 20931-37-7
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Appearance |
Yellow solid solid
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SMILES |
CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)OC)CC=C(C)C)O)C
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InChi Key |
GNRIZKKCNOBBMO-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
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Chemical Name |
1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
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Synonyms |
NSC 27593; NSC 139154; NSC 30552; Alpha-Mangostin; NSC27593; NSC139154; NSC30552
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~110 mg/mL (~267.99 mM)
H2O : < 0.1 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (6.70 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.4363 mL | 12.1815 mL | 24.3629 mL | |
5 mM | 0.4873 mL | 2.4363 mL | 4.8726 mL | |
10 mM | 0.2436 mL | 1.2181 mL | 2.4363 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT06039774 | Recruiting | Drug: Placebo Drug: α-Mangostin Hydrogel Film With Chitosan Alginate Base |
Recurrent Aphthous Stomatitis | Universitas Padjadjaran | December 4, 2023 | Phase 2 |