| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| 25g |
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Purity: ≥98%
Amikacin is an aminoglycoside antibiotic used for a number of bacterial infections including joint infections, intra-abdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used for the treatment of multidrug-resistant tuberculosis. It is used either by injection into a vein or muscle. Amikacin, like other aminoglycoside antibiotics, can cause hearing loss, balance problems, and kidney problems. Other side effects include paralysis, resulting in the inability to breathe. If used during pregnancy it may cause permanent deafness in the baby. Amikacin works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to produce proteins.
| Targets |
Aminoglycoside
|
|---|---|
| ln Vitro |
When treating infections brought on by organisms resistant to other aminoglycosides, amikacin has clear benefits. Relatively few enzymes that modify arninoglycosides have an impact on amikacin. Amikacin is effective in treating infections brought on by Mycobacterium avium-intracellulare, Nocardia asteroides, and a few species of "rapid-growing" mycobacteria, such as M. chelonae and M. fortuitumi[1].
With an LD50 value of 453 μM, amikacin (100-1500 μM) reliably causes a dose-dependent loss of lateral line zebrafish hair cells[3]. |
| ln Vivo |
Treatment with amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) raises the risk of significant hearing loss in rats in vivo[3].
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| Animal Protocol |
Animal Model: Male Fischer 344 rats (40-50-day-old)[3]
Dosage: 320 mg/kg Administration: Subcutaneous injection; daily; for 10 days Result: Induced hearing loss in rats. |
| References |
| Molecular Formula |
C22H47N5O21S2
|
|---|---|
| Molecular Weight |
781.7595
|
| Elemental Analysis |
C, 33.80; H, 6.06; N, 8.96; O, 42.98; S, 8.20
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| CAS # |
39831-55-5
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| Related CAS # |
Amikacin hydrate;1257517-67-1;Amikacin sulfate;149022-22-0;Amikacin;37517-28-5
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| Appearance |
White to off-white crystalline powder.
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| SMILES |
NCC[C@@H](C(N[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)N)O)CO)O)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CN)N)=O)O.OS(=O)(O)=O.OS(=O)(O)=O
|
| InChi Key |
FXKSEJFHKVNEFI-GCZBSULCSA-N
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| InChi Code |
InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
|
| Chemical Name |
(S)-4-amino-N-((1R,2S,3S,4R,5S)-5-amino-2-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide bis(sulfate)
|
| Synonyms |
BAY-416651 sulfate; BAY416651 sulfate; BAY416651 sulfate; Amikacin sulfate; Amitrex; Antibiotic BB-K8 sulfate; BB-K8; Biklin; Biodacyn; Chemacin; Fabianol; Kaminax; Kancin-Gap; Likacin; Lukadin; BB K8; BBK8
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~127.92 mM)
DMSO : ~1 mg/mL (~1.28 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (63.96 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2792 mL | 6.3958 mL | 12.7916 mL | |
| 5 mM | 0.2558 mL | 1.2792 mL | 2.5583 mL | |
| 10 mM | 0.1279 mL | 0.6396 mL | 1.2792 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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