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250mg |
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500mg |
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1g |
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10g |
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Purity: ≥98%
Amygdalin, also known as bitter almonds, is a natural glycoside found in the seeds of the tree Prunus dulcis and from semen armeniacae amarae. It can also been isolated from the stones of rosaceous fruits, such as apricots, peaches, almond, cherries, and plums.Amygdalin is a cyanide containing glycoside which has beend used as a substrate to characterize a variety of enzymes, including maltases, emulsins and β-glucosidases.
ln Vitro |
Amygdalin possesses anticancer properties. There has been some advancement in amygdalin's anti-tumor mechanism [1]. Exonuclease 1, ATP-binding cassette, subfamily F, member 2, MRE11 meiotic recombination 11 homolog A, topoisomerase (DNA) I, and FK506 Binding protein 12-rapamycin-related protein 1 are among the genes that are specifically downregulated by amygdalin. RT-PCR analysis revealed that amygdalin treatment also decreased the mRNA levels of these genes in SNU-C4 human colon cancer cells [2].
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ln Vivo |
Amygdalin functions as an analgesic with antinociceptive and anti-inflammatory properties, effectively relieving inflammatory pain. Amygdalin injected intramuscularly dramatically decreased formalin-induced tonic pain both early (in the first ten minutes following injection) and late (in the ten to thirty minute range). Later on, and in the dose range below 1 mg/kg, amygdalin decreases formalin-induced pain in a dose-dependent way [3].
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References |
[1]. Song Z, et al. Advanced research on anti-tumor effects of amygdalin. J Cancer Res Ther. 2014 Aug;10 Suppl 1:3-7.
[2]. Park HJ,et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol. 2005 Sep 7;11(33):5156-61. [3]. Hwang HJ,et al. Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biol Pharm Bull. 2008 Aug;31(8):1559-64 |
Molecular Formula |
C20H27NO11
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Molecular Weight |
457.42
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CAS # |
29883-15-6
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Related CAS # |
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O1[C@]([H])([C@@]([H])([C@]([H])([C@@]([H])([C@@]1([H])C([H])([H])O[C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])O[H])O1)O[H])O[H])O[H])O[H])O[H])O[H])O[C@@]([H])(C#N)C1C([H])=C([H])C([H])=C([H])C=1[H]
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InChi Key |
XUCIJNAGGSZNQT-SWRVSKMJSA-N
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InChi Code |
InChI=1S/C20H27NO11/c21-6-10(9-4-2-1-3-5-9)30-20-18(28)16(26)14(24)12(32-20)8-29-19-17(27)15(25)13(23)11(7-22)31-19/h1-5,10-20,22-28H,7-8H2/t10?,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-/m1/s1
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Chemical Name |
[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy](phenyl)acetonitrile
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.47 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: 100 mg/mL (218.61 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.1862 mL | 10.9309 mL | 21.8617 mL | |
5 mM | 0.4372 mL | 2.1862 mL | 4.3723 mL | |
10 mM | 0.2186 mL | 1.0931 mL | 2.1862 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.