Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Angeloylgomisin H is a naturally occurring lignin compound isolated from Schisandra rubriflora, witch can improve insulin-stimulated glucose uptake by activating PPAR-γ.
Molecular Formula |
C28H36O8
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Molecular Weight |
500.5806
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Exact Mass |
500.2410181
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CAS # |
66056-22-2
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Related CAS # |
66056-22-2
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Appearance |
solid
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SMILES |
C/C=C(/C)\C(=O)OC1=C2C(=CC(=C1OC)OC)C[C@@H]([C@@](CC3=CC(=C(C(=C32)OC)OC)OC)(C)O)C
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InChi Key |
ZSAUXCVJDYCLRS-XSIRQHFTSA-N
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InChi Code |
InChI=1S/C28H36O8/c1-10-15(2)27(29)36-26-21-17(12-19(31-5)24(26)34-8)11-16(3)28(4,30)14-18-13-20(32-6)23(33-7)25(35-9)22(18)21/h10,12-13,16,30H,11,14H2,1-9H3/b15-10-/t16-,28-/m0/s1
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Chemical Name |
[(9S,10S)-10-hydroxy-4,5,14,15,16-pentamethoxy-9,10-dimethyl-3-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaenyl] (Z)-2-methylbut-2-enoate
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Synonyms |
Angeloylgomisin H
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~250 mg/mL (~499.4 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9977 mL | 9.9884 mL | 19.9768 mL | |
5 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL | |
10 mM | 0.1998 mL | 0.9988 mL | 1.9977 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Chemical structure of angeloylgomisin H (A) and rutin (IS, B). Int J Clin Exp Med . 2015 Oct 15;8(10):17968-76. eCollection 2015. td> |
Mass spectrum of angeloylgomisin H (A) and rutin (IS, B). Int J Clin Exp Med . 2015 Oct 15;8(10):17968-76. eCollection 2015. td> |
Representative UPLC-MS/MS chromatograms of angeloylgomisin H and rutin (IS), (A) blank plasma; (B) blank plasma spiked with angeloylgomisin H (5 ng/mL) and IS (50 ng/mL); (C) a rat plasma sample 3 h after intravenous administration of single dosage 2 mg/kg angeloylgomisin H. Int J Clin Exp Med . 2015 Oct 15;8(10):17968-76. eCollection 2015. td> |
Mean plasma concentration time profile after oral (10 mg/kg, po) and intravenous (2 mg/kg, iv) administration of angeloylgomisin H in rats. Int J Clin Exp Med . 2015 Oct 15;8(10):17968-76. eCollection 2015. td> |