Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
Apigetrin (Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigenin 7-glucoside) is a naturally occuring flavanoid derived from dandelions and exhibits significant anti-proliferative and antioxidant activity, scavengers of ROS. It may inhibit neuroinflammation in BV-2 microglia and have a neuroprotective effect in HT22 hippocampal cells. This molecule may also hinder cancer progression by inhibiting various pathways such as STAT3/JAK2.
ln Vitro |
After 24 and 48 hours of incubation, apigenin 7-glucoside demonstrated strong antiproliferative action on B16F10 melanoma cells. The number of cells in the subG0/G1, S, and G2/M phases increased as a result of apigenin-7-glucoside, whereas the fraction of cells in the G0/G1 phase significantly decreased. In B16F10 melanoma cells, apigenin-7-glucoside increases tyrosinase activity, melanogenesis, and production [1]. Specifically, apigenin 7-glucoside inhibits myeloid differentiation while inducing CD34+ cells to differentiate toward the erythroid lineage. Strong antioxidant action against reactive oxygen species (ROS) is exhibited by apigenin 7-glucoside in vitro in a concentration-dependent manner [2].
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References |
[1]. Nasr Bouzaiene N et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Life Sci. 2016 Jan 1;144:80-5.
[2]. Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation. 2015 Jun;89(5):146-55. |
Molecular Formula |
C21H20O10
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Molecular Weight |
432.3775
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CAS # |
578-74-5
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Related CAS # |
Apigenin;520-36-5
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
c12c(=O)cc(c3ccc(O)cc3)oc1cc(cc2O)O[C@@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO
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InChi Key |
KMOUJOKENFFTPU-OBJCFNGXSA-N
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InChi Code |
1S/C21H20O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-7,16,18-24,26-28H,8H2/t16-,18+,19+,20-,21-/m1/s1
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Chemical Name |
7-(beta-D-Glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
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Synonyms |
Apigenin-7-O-β-D-glucopyranoside Cosmosiin Apigenin 7-glucoside
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~231.28 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.78 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.78 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3128 mL | 11.5639 mL | 23.1278 mL | |
5 mM | 0.4626 mL | 2.3128 mL | 4.6256 mL | |
10 mM | 0.2313 mL | 1.1564 mL | 2.3128 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.